dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016717
Uniprot Accession Q12516; SRF1_YEAST; D6VRL6; P89897; Q7LGS2;
Genbank Protein ID NP_010149.1;
Genbank Nucleotide ID NM_001180192.1;
Protein Name Regulator of phospholipase D SRF1
Protein Synonyms/Alias SPO14 regulatory factor 1;
Gene Name SRF1
Gene Synonyms/Alias YDL133W;D2185;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16:0 platelet activating factor.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
39VDLEKNQTVRKSGSLcurated19823750
43KNQTVRKSGSLEALQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 21126336; 20702584; 19823750;
45QTVRKSGSLEALQNAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
60KIHVPKHSDGSPLDYcurated25315811
63VPKHSDGSPLDYPKLPHOSIDA;curated21081558; 22817900; 19795423; 25315811
122KWGQFASTIGCHSAYPhosphoGRID 2.0;curated21177495; 22817900
127ASTIGCHSAYTRDQNPhosphoGRID 2.0;curated21177495; 22817900
135AYTRDQNYNPSHKSYPhosphoGRID 2.0;curated21177495; 22817900
138RDQNYNPSHKSYDGYcurated22817900; 25315811; 20377248
152YSLSSSTSSKNAALRcurated25315811
167EILGDMCSEWGGEERdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20702584; 19779198; 19060867;
219DNKKNPESPESVHNKcurated26040289; 25315811
222KNPESPESVHNKVYKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040289; 25315811
228ESVHNKVYKSDWVNEPhosphoGRID 2.021126336
Sequence
(Fasta)		MGDSNSSQEA YSDTTSTNAS RIADQNQLNL NVDLEKNQTV RKSGSLEALQ NAKIHVPKHS 60
DGSPLDYPKL NTYTFVPTTV PPYVLEAQFD KLRLQDKGTV DGNVTDDKNL PKEFKWGQFA 120
STIGCHSAYT RDQNYNPSHK SYDGYSLSSS TSSKNAALRE ILGDMCSEWG GEERLEGVLH 180
SEIGANLEFN TTEERKEWLQ YIEKVKDFYY GDNKKNPESP ESVHNKVYKS DWVNELNKER 240
EKWRRLKQRK LQQWRPPLTS LLLDNQYLIL GLRIFTGILS CISLALAIKI FQNSRSNNTI 300
SESKIGQQPS TIMAICVNAV AIAYIIYIAH DEFAGKPVGL RNPLSKLKLI LLDLLFIIFS 360
SANLALAFNT RFDKEWVCTS IRRSNGSTYG YPKIPRICRK QEALSAFLFV ALFMWVITFS 420
ISIVRVVEKV SSITNRN 438
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro
PROSITE
Pfam
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0016042--P:lipid catabolic process
GO:0043085--P:positive regulation of catalytic activity