dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016713
Uniprot Accession Q12511; PDP1_YEAST; D6W2F1;
Genbank Protein ID NP_014733.1;
Genbank Nucleotide ID NM_001183509.1;
Protein Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Protein Synonyms/Alias
Gene Name PTC5
Gene Synonyms/Alias PPP1;YOR090C;YOR3157C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
97KDYSTNTSGNINMPScurated23607784
104SGNINMPSPNPKGTEcurated23607784
487DNNSSSPSGSNPEYLcurated22817900
Sequence
(Fasta)		MSPLTRTVAI KKTVKVLSKC QSGREYTQKF LQRAYSTSHA NSTYYSRTKL FISSHSKALN 60
IALLSGSLLL TYSYYSPKKI LSLDTINGIK DYSTNTSGNI NMPSPNPKGT ETQKSQRSQN 120
DQSVLILNDS KIEAKLHDRE ESHFVNRGTG IFRYDVAQLP SNHPIEDDHV EQIITIPIES 180
EDGKSIEKDL YFFGIFDGHG GPFTSEKLSK DLVRYVAYQL GQVYDQNKTV FHSDPNQLID 240
SAISKGFLKL DNDLVIESFR KLFQDPNNTN IANTLPAISG SCALLSLYNS TNSILKVAVT 300
GDSRALICGL DNEGNWTVKS LSTDQTGDNL DEVRRIRKEH PGEPNVIRNG RILGSLQPSR 360
AFGDYRYKIK EVDGKPLSDL PEVAKLYFRR EPRDFKTPPY VTAEPVITSA KIGENTKFMV 420
MGSDGLFELL TNEEIASLVI RWMDKNMNLA PVKAEPGKLP KVIDVSEDKE AQRPAFRYKD 480
NNSSSPSGSN PEYLIEDKNV ATHLIRNALS AGGRKEYVSA LVSIPSPMSR RYRDDLTVTV 540
AFFGDSGTPS IVSNATSIVM NPEATTKPKP RL 573
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR015655--PP2C
IPR000222--PP2C_BS
IPR001932--PPM-type_phosphatase_dom
PROSITE

PS01032--PPM_1
PS51746--PPM_2
Pfam

PF00481--PP2C
Gene Ontology

GO:0005758--C:mitochondrial intermembrane space
GO:0005739--C:mitochondrion
GO:0004741--F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872--F:metal ion binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0043085--P:positive regulation of catalytic activity
GO:0006470--P:protein dephosphorylation
GO:0050790--P:regulation of catalytic activity