dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016712
Uniprot Accession Q12510; CMR1_YEAST; D6VRJ4;
Genbank Protein ID NP_010125.1;
Genbank Nucleotide ID NM_001180216.1;
Protein Name DNA damage-binding protein CMR1
Protein Synonyms/Alias Changed mutation rate protein 1;
Gene Name CMR1
Gene Synonyms/Alias YDL156W;D1536;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro (PubMed:22367945). May be involved in DNA-metabolic processes (PubMed:23349438).
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
62TNTRATKSASPTLPTPhosphoGRID 2.021126336
64TRATKSASPTLPTRRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20702584; 19779198; 19366988;
69SASPTLPTRRSRRLRdbPTM 3.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900
79SRRLRGESADDVKGIcurated25315811
99NQLLKMGSPDGQDKNPhosphoGRID 2.0;curated19779198; 17287358; 22817900; 25315811; 19547744
224RDEPLADSEEDRMEEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22817900;
426VKSRDHLSAKLEPKLcurated22817900
Sequence
(Fasta)		MPELTEFQKK RLENIKRNND LLKKLHLSGV ASQIKHEAGV LEKSRAPAKK KQKTTNTRAT 60
KSASPTLPTR RSRRLRGESA DDVKGIPNVN DNQLLKMGSP DGQDKNFIDA IKEKPVIGDV 120
KLSDLIKDED ESALLEKFKR FNNGNFSSGD FFEEIKKRQG DVTGMDEFDL DLYDVFQPNE 180
IKITYERISA TYFHPAMEKK LIIAGDTSGT VGFWNVRDEP LADSEEDRME EPDITRVKLF 240
TKNVGRIDCF PADTSKILLT SYDGSIRSVH LNNLQSEEVL TLKNEYDDSL GISDCQFSYE 300
NPNVLFLTTL GGEFTTFDTR VKKSEYNLRR LADKKIGSMA INPMRPYEIA TGSLDRTLKI 360
WDTRNLVKKP EWSQYEDYPS HEIVSTYDSR LSVSAVSYSP TDGTLVCNGY DDTIRLFDVK 420
SRDHLSAKLE PKLTIQHNCQ TGRWTSILKA RFKPNKNVFA IANMKRAIDI YNSEGQQLAH 480
LPTATVPAVI SWHPLRNWIA GGNSSGKIFL FTDDSGTIKQ EE 523
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0034399--C:nuclear periphery
GO:0003677--F:DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000001--P:regulation of DNA damage checkpoint