dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016702
Uniprot Accession Q12494; KCS1_YEAST; D6VS03; P89899; Q7LGR2;
Genbank Protein ID NP_010300.3;
Genbank Nucleotide ID NM_001180325.3;
Protein Name Inositol hexakisphosphate kinase 1
Protein Synonyms/Alias
Gene Name KCS1
Gene Synonyms/Alias YDR017C;PZF1050;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance.
Phosphorylation Sites
 dbPAF PTMs: 51 (View all)
PositionPeptidesSourceReferences ( PMIDs )
27QHLRQKESEGCITTLcurated25704821; 22369663; 25315811
55VLHGRKASTYLRIFRcurated26040289; 25704821
97RSEATPKSVPEGLQVPhosphoGRID 2.0;curated19779198; 22817900; 24961812; 25315811
113EKKNNPDTLSSSLSScurated25704821
115KNNPDTLSSSLSSFIPhosphoPep 2.019060867
116NNPDTLSSSLSSFILcurated19823750; 24961812
117NPDTLSSSLSSFILSPhosphoPep 2.0;curated19060867; 26040289; 24961812
119DTLSSSLSSFILSNHcurated25704821
120TLSSSLSSFILSNHEcurated24961812
144VAHRNNITETGQGSGPhosphoGRID 2.021126336
150ITETGQGSGEDIAKQdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
183NVDEGCISPKSTYQEPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040406; 22817900; 23607784; 25315811;
205DLTLKPVSSATYYPHcurated24961812; 20377248
206LTLKPVSSATYYPHKdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812; 25315811;
210PVSSATYYPHKSKADdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
291QFVPHSESIKEKPNTcurated22817900; 20377248
396QSKDDFLSDLDQENNdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 21081558; 19366988;
434LNTEPTGTPLTHIHScurated24961812
441TPLTHIHSFPLEHSSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
469VHPHVKRSLSSSNQPdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated17563356; 16381945; 23193290; 20702584; 19779198; 19060867;
Sequence
(Fasta)		MDTSHEIHDK IPDTLREQQQ HLRQKESEGC ITTLKDLNVP ETKKLSSVLH GRKASTYLRI 60
FRDDECLADN NNGVDSNNGG SVTCADKITR SEATPKSVPE GLQVSEKKNN PDTLSSSLSS 120
FILSNHEEPA IKPNKHVAHR NNITETGQGS GEDIAKQQSH QPQVLHHQTS LKPIQNVDEG 180
CISPKSTYQE SLHGISEDLT LKPVSSATYY PHKSKADSGY EEKDKMENDI DTIQPATINC 240
ASGIATLPSS YNRHTFKVKT YSTLSQSLRQ ENVNNRSNEK KPQQFVPHSE SIKEKPNTFE 300
QDKEGEQADE EEDEGDNEHR EYPLAVELKP FTNRVGGHTA IFRFSKRAVC KALVNRENRW 360
YENIELCHKE LLQFMPRYIG VLNVRQHFQS KDDFLSDLDQ ENNGKNDTSN ENKDIEVNHN 420
NNDDIALNTE PTGTPLTHIH SFPLEHSSRQ VLEKEHPEIE SVHPHVKRSL SSSNQPSLLP 480
EVVLNDNRHI IPESLWYKYS DSPNSAPNDS YFSSSSSHNS CSFGERGNTN KLKRRDSGST 540
MINTELKNLV IREVFAPKCF RRKRNSNTTT MGNHNARLGS SPSFLTQKSR ASSHDASNTS 600
MKTLGDSSSQ ASLQMDDSKV NPNLQDPFLK KSLHEKISNA LDGSHSVMDL KQFHKNEQIK 660
HKNSFCNSLS PILTATNSRD DGEFATSPNY ISNAQDGVFD MDEDTGNETI NMDNHGCHLD 720
SGKNMIIKSL AYNVSNDYSH HDIESITFEE TSHTIVSKFI LLEDLTRNMN KPCALDLKMG 780
TRQYGVDAKR AKQLSQRAKC LKTTSRRLGV RICGLKVWNK DYYITRDKYF GRRVKVGWQF 840
ARVLARFLYD GKTIESLIRQ IPRLIKQLDT LYSEIFNLKG YRLYGASLLL MYDGDANKSN 900
SKRKKAANVK VNLIDFARCV TKEDAMECMD KFRIPPKSPN IEDKGFLRGV KSLRFYLLLI 960
WNYLTSDMPL IFDEVEMNDM ISEEADSNSF TSATGSKINF NSKWDWLDEF DKEDEEMYND 1020
PNSKLRQKWR KYELIFDAEP RYNDDAQVSD 1051
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR005522--IPK
PROSITE
Pfam

PF03770--IPK
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0033200--F:inositol heptakisphosphate 5-kinase activity
GO:0000829--F:inositol heptakisphosphate kinase activity
GO:0052723--F:inositol hexakisphosphate 1-kinase activity
GO:0052724--F:inositol hexakisphosphate 3-kinase activity
GO:0000832--F:inositol hexakisphosphate 5-kinase activity
GO:0000828--F:inositol hexakisphosphate kinase activity
GO:0000827--F:inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0008440--F:inositol-1,4,5-trisphosphate 3-kinase activity
GO:0032958--P:inositol phosphate biosynthetic process
GO:0010919--P:regulation of inositol phosphate biosynthetic process