dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016701
Uniprot Accession Q12493; NKP1_YEAST; D6VT17;
Genbank Protein ID NP_010671.4;
Genbank Nucleotide ID NM_001180691.3;
Protein Name Central kinetochore subunit NKP1
Protein Synonyms/Alias Non-essential kinetochore protein 1;
Gene Name NKP1
Gene Synonyms/Alias YDR383C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
222AVKTFGNSPEKREKIdbPTM 3.0;SysPTM 2.0;UniProt18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)
MTDTYNSISN FIENELTALL SSDDYLMDDL AGELPNEVCR LLKAQVIEKR KDAMSRGKQD 60
LLSKEIYDNE SELRASQSQQ IMELVGDIPK YSLGSELRNR VEGEPQSTSI ERLIEDVLKL 120
PQMEVADEEE VEVENDLKVL SEYSNLRKDL ILKCQALQIG ESKLSDILSQ TNSINSLTTS 180
IKEASEDDDI SEYFATYNGK LVVALEEMKL LLEEAVKTFG NSPEKREKIK KILSELKK 239
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro
PROSITE
Pfam
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0000776--C:kinetochore
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division