Tag |
Content |
dbPAF ID |
dbPAF-0016700 |
Uniprot Accession |
Q12491; YB21B_YEAST; D6VPQ4; Q05679; |
Genbank Protein ID |
NP_009450.1; |
Genbank Nucleotide ID |
NM_001180050.2; |
Protein Name |
Transposon Ty2-B Gag-Pol polyprotein |
Protein Synonyms/Alias |
TY2A-TY2B;Transposon Ty2 TYA-TYB polyprotein; |
Gene Name |
TY2B-B |
Gene Synonyms/Alias |
YBLWTy2-1 POL;YBL100W-B;YBL0822;YBL101W-B; |
Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
NCBI Taxa ID |
559292 |
Functional Description (View all) |
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).Functional Description
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
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Phosphorylation Sites
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dbPAF PTMs: 4 |
Sequence (Fasta) | MESQQLHQNP HSLHGSAYAS VTSKEVSSNQ DPLAVSASNL PEFDRDSTKV NSQQETTPGT 60 SAVPENHHHV SPQPASVPPP QNGQYQQHGM MTPNKAMASN WAHYQQPSMM TCSHYQTSPA 120 YYQPDPHYPL PQYIPPLSTS SPDPIDSQDQ HSEVPQAKTK VRNNVLPPHT LTSEENFYTW 180 VKFYIRFLKN SNLGDIIPND QGEIKRQMTY EEHAYIYNTF QAFAPFHLLP TWVKQILEIN 240 YADILTVLCK SVSKMQTNNQ ELKDWIALAN LEYDGSTSAD TFEITVSTII QRLKENNINV 300 SDRLACQLIL KGLSGDFKYL RNQYRTKTNM KLSQLFAEIQ LIYDENKIMN LNKPSQYKQH 360 SEYKNVSRTS PNTTNTKVTT RNYHRTNSSK PRAAKAHNIA TSSKFSRVNN DHINESTVSS 420 QYLSDDNELS LGQQQKESKP THTIDSNDEL PDHLLIDSGA SQTLVRSAHY LHHATPNSEI 480 NIVDAQKQDI PINAIGNLHF NFQNGTKTSI KALHTPNIAY DLLSLSELAN QNITACFTRN 540 TLERSDGTVL APIVKHGDFY WLSKKYLIPS HISKLTINNV NKSKSVNKYP YPLIHRMLGH 600 ANFRSIQKSL KKNAVTYLKE SDIEWSNAST YQCPDCLIGK STKHRHVKGS RLKYQESYEP 660 FQYLHTDIFG PVHHLPKSAP SYFISFTDEK TRFQWVYPLH DRREESILNV FTSILAFIKN 720 QFNARVLVIQ MDRGSEYTNK TLHKFFTNRG ITACYTTTAD SRAHGVAERL NRTLLNDCRT 780 LLHCSGLPNH LWFSAVEFST IIRNSLVSPK NDKSARQHAG LAGLDITTIL PFGQPVIVNN 840 HNPDSKIHPR GIPGYALHPS RNSYGYIIYL PSLKKTVDTT NYVILQDNQS KLDQFNYDTL 900 TFDDDLNRLT AHNQSFIEQN ETEQSYDQNT ESDHDYQSEI EINSDPLVND FSSQSMNPLQ 960 LDHEPVQKVR ALKEVDADIS EYNILPSPVR SRTPHIINKE STEMGGTIES DTTSPRHSST 1020 FTARNQKRPG SPNDMIDLTS QDRVNYELEN IKTTRLGGTE EPYIQRNSDT NIKYRTTNST 1080 PSIDDRSPDS DSTTPIISIE TKAACDNTPS IDTDPPEYRS SDHATPNIMP DKSSKNVTAD 1140 SILDDLPLPD LTNKSPTDTS DVSKDIPHIH SRQTNSSLGG MDDSNVLTTT KSKKRSLEDN 1200 ETEIEVSRDT WNNKNMRSLE PPRSKKRINL IAAIKGVKSI KPVRTTLRYD EAITYNEDNK 1260 EKDRYIEAYH KEINQLLRMN TWDTNKYYDR NDIDPKKVIN SMFIFNKKRD GTHKARFVAR 1320 GDIQHPDTYD SDMQSNTVHH YALMTSLSIA LDNDYYITQL DISSAYLYAD IKEELYIRPP 1380 PHLGLNDKLL RLRKSLYGLK QSGANWYETI KSYLINCCDM QEVRGWSCVF KNSQVTICLF 1440 VDDMILFSKD LNANEKIITT LKKQYDTKII NLGESDNEIQ YDILGLEIKY QRSKYMKLGM 1500 EKSLTEKLPK LNVPLNPKGK KLSAPGQPGH YIDQDELEID EDEYKEKVHE MQKLIGLASY 1560 VGYKFRFDLL YYINTLAQHI LFPSRQVLDM TYELIQFMWD TRDKQLIWHK NKPTKPDNKL 1620 VAISDASYGN QPYYKSQIGN IFLLNGKVIG GKSTKASLTC TSTTEAEIHA VSEAIPLLNN 1680 LSHLVQELNK KPIIKGLLTD SRSTISIIKS TNEEKFRNRF FGTKAMRLRD EVSGNNLYVY 1740 YIETKKNIAD VMTKPLPIKT FKLLTNKWIH
1771Fasta Sequence
>Q12491|TY2B-B|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) MESQQLHQNPHSLHGSAYASVTSKEVSSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQDQHSEVPQAKTKVRNNVLPPHTLTSEENFYTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDNQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSMNPLQLDHEPVQKVRALKEVDADISEYNILPSPVRSRTPHIINKESTEMGGTIESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYELENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSPDSDSTTPIISIETKAACDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTNKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNEDNKEKDRYIEAYHKEINQLLRMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANEKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLSAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
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Keyword |
KW-0064--Aspartyl protease KW-0067--ATP-binding KW-0181--Complete proteome KW-0963--Cytoplasm KW-0229--DNA integration KW-0233--DNA recombination KW-0238--DNA-binding KW-0239--DNA-directed DNA polymerase KW-0255--Endonuclease KW-0378--Hydrolase KW-0460--Magnesium KW-0479--Metal-binding KW-0511--Multifunctional enzyme KW-0540--Nuclease KW-0547--Nucleotide-binding KW-0548--Nucleotidyltransferase KW-0539--Nucleus KW-0645--Protease KW-1185--Reference proteome KW-0688--Ribosomal frameshifting KW-0694--RNA-binding KW-0695--RNA-directed DNA polymerase KW-0808--Transferase KW-0814--Transposable element KW-0815--Transposition KW-0917--Virion maturation KW-1188--Virus exit from host cell KW-0862--Zinc KW-0863--Zinc-finger
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Interpro |
IPR025724--GAG-pre-integrase_dom IPR001584--Integrase_cat-core IPR015820--Retrotransposon_Ty1A_N IPR012337--RNaseH-like_dom IPR013103--RVT_2
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PROSITE |
PS50994--INTEGRASE
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Pfam |
PF13976--gag_pre-integrs PF00665--rve PF07727--RVT_2 PF01021--TYA
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005634--C:nucleus GO:0000943--C:retrotransposon nucleocapsid GO:0004190--F:aspartic-type endopeptidase activity GO:0005524--F:ATP binding GO:0003677--F:DNA binding GO:0003887--F:DNA-directed DNA polymerase activity GO:0046872--F:metal ion binding GO:0008233--F:peptidase activity GO:0004540--F:ribonuclease activity GO:0003723--F:RNA binding GO:0003964--F:RNA-directed DNA polymerase activity GO:0004523--F:RNA-DNA hybrid ribonuclease activity GO:0071897--P:DNA biosynthetic process GO:0015074--P:DNA integration GO:0006310--P:DNA recombination GO:0090501--P:RNA phosphodiester bond hydrolysis GO:0006278--P:RNA-dependent DNA replication GO:0032197--P:transposition, RNA-mediated GO:0019076--P:viral release from host cell
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