dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016699
Uniprot Accession Q12490; YB11B_YEAST; D6VPZ6;
Genbank Protein ID NP_009549.1;
Genbank Nucleotide ID NM_001180048.2;
Protein Name Transposon Ty1-BL Gag-Pol polyprotein
Protein Synonyms/Alias Gag-Pol-p199;TY1A-TY1B;Transposon Ty1 TYA-TYB polyprotein;p190;
Gene Name TY1B-BL
Gene Synonyms/Alias YBLWTy1-1 POL;YBL005W-B;YBL004W-A;YBL0325;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
1055FRHSDSYSDNETNHTdbPTM 3.017330950; 16381945; 23193290
1062SDNETNHTNVPISSTdbPTM 3.017330950; 16381945; 23193290
1093EKRIIHRSPSIDTSSdbPTM 3.017330950; 16381945; 23193290
1095RIIHRSPSIDTSSSEdbPTM 3.017330950; 16381945; 23193290
Sequence
(Fasta)
MESQQLSQHS PIFHGSACAS VTSKEVQTTQ DPLDISASKT EECEKVSTQA NSQQPTTPPS 60
SAVPENHHHA SPQAAQVPLP QNGPYPQQRM MNTQQANISG WPVYGHPSLM PYPPYQMSPM 120
YAPPGAQSQF TQYPQYVGTH LNTPSPESGN SFPDSSSAKS NMTSTNQHVR PPPILTSPND 180
FLNWVKIYIK FLQNSNLGDI IPTATRKAVR QMTDDELTFL CHTFQLFAPS QFLPPWVKDI 240
LSVDYTDIMK ILSKSINKMQ SDTQEVNDIT TLATLHYNGS TPADAFEAEV TNILDRLNNN 300
GIPINNKVAC QFIMRGLSGE YKFLPYARHR CIHMTVADLF SDIHSMYEEQ QESKRNKSTY 360
RRSPSDEKKD SRTYTNTTKP KSITRNSQKP NNSQSRTARA HNVSTFNNSP GPDNDLIRGS 420
TTEPIQLKNT HDLHLGQELT ESTVNHTNHS DDELPGHLLL DSGASRTLIR SAHHIHSASS 480
NPDINVVDAQ KRNIPINAIG DLQFHFQDNT KTSIKVLHTP NIAYDLLSLN ELAAVDITAC 540
FTKNVLERSD GTVLAPIVKY GDFYWVSKKY LLPSNISVPT INNVHTSEST RKYPYPFIHR 600
MLAHANAQTI RYSLKNNTIT YFNESDVDWS SAIDYQCPDC LIGKSTKHRH IKGSRLKYQN 660
SYEPFQYLHT DIFGPVHNLP KSAPSYFISF TDETTKFRWV YPLHDRREDS ILDVFTTILA 720
FIKNQFQASV LVIQMDRGSE YTNRTLHKFL EKNGITPCYT TTADSRAHGV AERLNRTLLD 780
DCRTQLQCSG LPNHLWFSAI EFSTIVRNSL ASPKSKKSAR QHAGLAGLDI STLLPFGQPV 840
IVNDHNPNSK IHPRGIPGYA LHPSRNSYGY IIYLPSLKKT VDTTNYVILQ GKESRLDQFN 900
YDALTFDEDL NRLTASYQSF IASNEIQQSN DLNIESDHDF QSDIELYPEQ PRNVLSKAVS 960
PTDSTPPSTH TEDSKRVSKT NIRAPREVDP NISESNILPS KKRSSTPQIS DIESTDSGGM 1020
HRLDVPLLAP MSQSNTHESS YASKSKDFRH SDSYSDNETN HTNVPISSTG GTNNKTVPQT 1080
SEQETEKRII HRSPSIDTSS SESNSLHHVV PIKTSDTCPK ENTEESIIAD LPLPDLPPEP 1140
PTELSDSFKE LPPINSRQTN SSLGGIGDSN AYTTINSKKR SLEDNETEIK VSRDTWNTKN 1200
MRSLEPPRSK KRIHLIAAVK AVKSIKPIRT TLRYDEAITY NKDIKEKEKY IEAYHKEVNQ 1260
LLKMKTWDTD KYYDRKEIDP KRVINSMFIF NRKRDGTHKA RFVARGDIQH PDTYDSGMQS 1320
NTVHHYALMT SLSLALDNNY HITQLDISSA YLYADIKEEL YIRPPPHLGM NDKLIRLKKS 1380
LYGLKQSGAN WYETIKSYLI KQCGMEEVRG WSCVFKNSQV TICLFVDDMV LFSKNLNSNK 1440
RIIDKLKMQY DTKIINLGES DEEIQYDILG LEIKYQRGKY MKLGMENSLT EKIPKLNVPL 1500
NPKGRKLSAP GQPGLYIDQQ ELELEEDDYK MKVHEMQKLI GLASYVGYKF RFDLLYYINT 1560
LAQHILFPSK QVLDMTYELI QFIWNTRDKQ LIWHKSKPVK PTNKLVVISD ASYGNQPYYK 1620
SQIGNIYLLN GKVIGGKSTK ASLTCTSTTE AEIHAISESV PLLNNLSYLI QELDKKPITK 1680
GLLTDSKSTI SIIISNNEEK FRNRFFGTKA MRLRDEVSGN HLHVCYIETK KNIADVMTKP 1740
LPIKTFKLLT NKWIH 1756
Keyword

KW-0064--Aspartyl protease
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0229--DNA integration
KW-0233--DNA recombination
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0540--Nuclease
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0688--Ribosomal frameshifting
KW-0694--RNA-binding
KW-0695--RNA-directed DNA polymerase
KW-0808--Transferase
KW-0814--Transposable element
KW-0815--Transposition
KW-0917--Virion maturation
KW-1188--Virus exit from host cell
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001969--Aspartic_peptidase_AS
IPR001584--Integrase_cat-core
IPR015820--Retrotransposon_Ty1A_N
IPR012337--RNaseH-like_dom
IPR013103--RVT_2

PROSITE

PS00141--ASP_PROTEASE
PS50994--INTEGRASE

Pfam

PF00665--rve
PF07727--RVT_2
PF01021--TYA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000943--C:retrotransposon nucleocapsid
GO:0004190--F:aspartic-type endopeptidase activity
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0008233--F:peptidase activity
GO:0004540--F:ribonuclease activity
GO:0003723--F:RNA binding
GO:0003964--F:RNA-directed DNA polymerase activity
GO:0004523--F:RNA-DNA hybrid ribonuclease activity
GO:0071897--P:DNA biosynthetic process
GO:0015074--P:DNA integration
GO:0006310--P:DNA recombination
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0006278--P:RNA-dependent DNA replication
GO:0032197--P:transposition, RNA-mediated
GO:0019076--P:viral release from host cell