dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016693
Uniprot Accession Q12476; AIR2_YEAST; D6VRH7;
Genbank Protein ID NP_010106.1;
Genbank Nucleotide ID NM_001180235.1;
Protein Name Protein AIR2
Protein Synonyms/Alias Arginine methyltransferase-interacting RING finger protein 2;
Gene Name AIR2
Gene Synonyms/Alias YDL175C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
5---MEKNTAPFVVDTPhosphoGRID 2.021126336
15FVVDTAPTTPPDKLVdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19823750; 19795423;
16VVDTAPTTPPDKLVAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated15665377; 17563356; 18407956; 16381945; 23193290; 19823750;
31PSIEEVNSNPNELRAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 24961812; 25315811
49QGRYFGVSDDDKDAIdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
256GRNKRRASNFHPPPYcurated25704821
Sequence
(Fasta)		MEKNTAPFVV DTAPTTPPDK LVAPSIEEVN SNPNELRALR GQGRYFGVSD DDKDAIKEAA 60
PKCNNCSQRG HLKKDCPHII CSYCGATDDH YSRHCPKAIQ CSKCDEVGHY RSQCPHKWKK 120
VQCTLCKSKK HSKERCPSIW RAYILVDDNE KAKPKVLPFH TIYCYNCGGK GHFGDDCKEK 180
RSSRVPNEDG SAFTGSNLSV ELKQEYYRHM NRNSDENEDY QFSESIYDED PLPRPSHKRH 240
SQNDHSHSGR NKRRASNFHP PPYQKSNVIQ PTIRGETLSL NNNISKNSRY QNTKVNVSSI 300
SENMYGSRYN PSTYVDNNSI SNSSNYRNYN SYQPYRSGTL GKRR 345
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016713--Air1/2_Saccharomycetales
IPR001878--Znf_CCHC
PROSITE

PS50158--ZF_CCHC
Pfam

PF00098--zf-CCHC
Gene Ontology

GO:0005730--C:nucleolus
GO:0031499--C:TRAMP complex
GO:0004652--F:polynucleotide adenylyltransferase activity
GO:0030674--F:protein binding, bridging
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0043629--P:ncRNA polyadenylation
GO:0071031--P:nuclear mRNA surveillance of mRNA 3'-end processing
GO:0071039--P:nuclear polyadenylation-dependent CUT catabolic process
GO:0071035--P:nuclear polyadenylation-dependent rRNA catabolic process
GO:0071036--P:nuclear polyadenylation-dependent snoRNA catabolic process
GO:0071037--P:nuclear polyadenylation-dependent snRNA catabolic process
GO:0071038--P:nuclear polyadenylation-dependent tRNA catabolic process
GO:0006400--P:tRNA modification