| Tag |
Content |
| dbPAF ID |
dbPAF-0016692 |
| Uniprot Accession |
Q12473; FRE6_YEAST; D6VXV7;
|
| Genbank Protein ID |
NP_013049.1;
|
| Genbank Nucleotide ID |
NM_001181871.1;
|
| Protein Name |
Ferric reductase transmembrane component 6 |
| Protein Synonyms/Alias |
Ferric-chelate reductase 6; |
| Gene Name |
FRE6 |
| Gene Synonyms/Alias |
YLL051C;L0593; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol.Functional Description
Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 359 | KISNKQLYWKFGIAS | PhosphoGRID 2.0 | 21126336 |
|
Sequence
(Fasta) | MHRTLLFLTW LISLTKAFNI KLPHTEKKDH LESNAVLACA SYINTLKWSF DSSVVPGFYS 60
TICSYSPAFD TWSLCIFNSL TDQIIPMDNT SFEESLGNVR KTCSFVDKKF SNISLEQYYS 120
SLNNASSHAL EDYGSIESLS TSIRVDRETR SRWIRAFHAH AYNLDISSVY GAYLTYYFVI 180
VGIIAVFFHM SHYNGLNRAL FASRFVNYIR GHFVLPTFLV DKHANHFKFL NVEVFTGLMP 240
NSLEAWIIFG YTLANIIFLS ISYIIDPYNL IFNSHLSQFT RLLADRSGIL AFTQFPLIII 300
FTARNSFLEF LTGVKFNSFI SFHKWIGRIM VLNATIHSLS YSLFAIINHA FKISNKQLYW 360
KFGIASITVL CVLLVLSLGI VRKRHYEFFL YTHIILALLF FYCCWQHVKI FNGWKEWIVV 420
SLLIWGLEKL FRIWNILQFR FPKATLINLN TSNNPHDEMF KVIIPKYNRR WHSKPGQYCF 480
IYFLHPLVFW QCHPFTIIDE GEKCVLVIKP KSGLTRFIYN HILQSLNGKL QLRVAIEGPY 540
GPSNLHLDKF DHLLLLSGGT GLPGPLDHAI KLSRNPDKPK SIDLIMAIKN PSFLNGYKSE 600
ILELKNSRSH VNVQVYLTQK TAVTKAANAR DQLIHFDDIM TELTSFAHIG NARPNFSNVI 660
ENAIKSTPPG DSLAVVCCGP PVLVDDVRNT VSQKLLGYPE RIIEYFEEYQ CW
713Fasta Sequence
>Q12473|FRE6|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MHRTLLFLTWLISLTKAFNIKLPHTEKKDHLESNAVLACASYINTLKWSFDSSVVPGFYSTICSYSPAFDTWSLCIFNSLTDQIIPMDNTSFEESLGNVRKTCSFVDKKFSNISLEQYYSSLNNASSHALEDYGSIESLSTSIRVDRETRSRWIRAFHAHAYNLDISSVYGAYLTYYFVIVGIIAVFFHMSHYNGLNRALFASRFVNYIRGHFVLPTFLVDKHANHFKFLNVEVFTGLMPNSLEAWIIFGYTLANIIFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFISFHKWIGRIMVLNATIHSLSYSLFAIINHAFKISNKQLYWKFGIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLIWGLEKLFRIWNILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHSKPGQYCFIYFLHPLVFWQCHPFTIIDEGEKCVLVIKPKSGLTRFIYNHILQSLNGKLQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLIMAIKNPSFLNGYKSEILELKNSRSHVNVQVYLTQKTAVTKAANARDQLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLVDDVRNTVSQKLLGYPERIIEYFEEYQCW
|
| Keyword |
KW-0181--Complete proteome
KW-0249--Electron transport
KW-0274--FAD
KW-0285--Flavoprotein
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0408--Iron
KW-0410--Iron transport
KW-0472--Membrane
KW-0479--Metal-binding
KW-0521--NADP
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0926--Vacuole
|
| Interpro |
IPR013112--FAD-bd_8
IPR017927--Fd_Rdtase_FAD-bd
IPR013130--Fe3_Rdtase_TM_dom
IPR013121--Fe_red_NAD-bd_6
|
| PROSITE |
PS51384--FAD_FR
|
| Pfam |
PF08022--FAD_binding_8
PF01794--Ferric_reduct
PF08030--NAD_binding_6
|
| Gene Ontology |
GO:0000329--C:fungal-type vacuole membrane
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0008823--F:cupric reductase activity
GO:0052851--F:ferric-chelate reductase (NADPH) activity
GO:0000293--F:ferric-chelate reductase activity
GO:0046872--F:metal ion binding
GO:0015677--P:copper ion import
GO:0006880--P:intracellular sequestering of iron ion
GO:0006826--P:iron ion transport
|
