dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016678
Uniprot Accession Q12452; ERG27_YEAST; D6VYA1;
Genbank Protein ID NP_013201.1;
Genbank Nucleotide ID NM_001181987.1;
Protein Name 3-keto-steroid reductase
Protein Synonyms/Alias
Gene Name ERG27
Gene Synonyms/Alias YLR100W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Responsible for the reduction of the keto group on the C-3 of sterols. Also facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
343LKDQIVETRTPI---PhosphoGRID 2.019779198
345DQIVETRTPI-----dbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 16381945; 23193290; 19823750; 19795423;
Sequence
(Fasta)		MNRKVAIVTG TNSNLGLNIV FRLIETEDTN VRLTIVVTSR TLPRVQEVIN QIKDFYNKSG 60
RVEDLEIDFD YLLVDFTNMV SVLNAYYDIN KKYRAINYLF VNAAQGIFDG IDWIGAVKEV 120
FTNPLEAVTN PTYKIQLVGV KSKDDMGLIF QANVFGPYYF ISKILPQLTR GKAYIVWISS 180
IMSDPKYLSL NDIELLKTNA SYEGSKRLVD LLHLATYKDL KKLGINQYVV QPGIFTSHSF 240
SEYLNFFTYF GMLCLFYLAR LLGSPWHNID GYKAANAPVY VTRLANPNFE KQDVKYGSAT 300
SRDGMPYIKT QEIDPTGMSD VFAYIQKKKL EWDEKLKDQI VETRTPI 348
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0444--Lipid biosynthesis
KW-0551--Lipid droplet
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
Interpro

IPR002198--DH_sc/Rdtase_SDR
IPR016040--NAD(P)-bd_dom
PROSITE
Pfam

PF00106--adh_short
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005811--C:lipid particle
GO:0000253--F:3-keto sterol reductase activity
GO:0006696--P:ergosterol biosynthetic process