dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016677
Uniprot Accession Q12451; OSH2_YEAST; D6VRX1; P89891;
Genbank Protein ID NP_010265.1;
Genbank Nucleotide ID NM_001180078.1;
Protein Name Oxysterol-binding protein homolog 2
Protein Synonyms/Alias
Gene Name OSH2
Gene Synonyms/Alias YDL019C;D2845;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Lipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides.
Phosphorylation Sites
 dbPAF PTMs: 59 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSREDLSIAPhosphoGRID 2.0;PHOSIDA;curated19823750; 19795423; 21081558; 26040406; 22369663; 26040289
7-MSREDLSIAEDLNQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated17563356; 16381945; 23193290; 15665377; 21081558; 19366988;
16AEDLNQVSKPLLKVKcurated26040406
89QVGDEKSSSKSDDGIcurated26040289
92DEKSSSKSDDGIHLDPhosphoGRID 2.0;curated19779198; 26040289
410SLALKNKSPALISHSPhosphoPep 2.0;curated19060867; 22817900; 19823750; 25315811
419ALISHSKTQGSLPEAcurated25704821; 24961812
422SHSKTQGSLPEASQYdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 18407956; 16381945; 23193290; 17330950; 19779198;
427QGSLPEASQYYQHTLPhosphoGRID 2.019779198
442HKEVIQPSSVSLYRRcurated20377248
443KEVIQPSSVSLYRRPcurated26447709; 20377248; 22817900
445VIQPSSVSLYRRPSNdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 15665377; 19779198;
447QPSSVSLYRRPSNNLPhosphoGRID 2.0;curated21177495; 22817900; 25521595
451VSLYRRPSNNLSVVSPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 26040406; 22369663; 22817900; 24961812;
455RRPSNNLSVVSSEIQPhosphoGRID 2.0;UniProt;curated19779198; 22817900; 24961812; 25521595; 25315811
458SNNLSVVSSEIQLNDPhosphoGRID 2.0;UniProt;curated19779198; 22817900; 24961812; 25521595
459NNLSVVSSEIQLNDNPhosphoGRID 2.0;UniProt;curated19779198; 22817900; 24961812; 25315811; 20377248
486IENRLDGSKTPVGVHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 19060867; 19366988;
488NRLDGSKTPVGVHTGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 19779198; 19060867;
494KTPVGVHTGSALQRVcurated24961812
Sequence
(Fasta)		MSREDLSIAE DLNQVSKPLL KVKLLEVLGQ GDFKHLKALV DNEFQPKDDP SVQQVLNLIL 60
HYAVQVAPIL LIKEIVAHWV DQVGDEKSSS KSDDGIHLDL NYQDENGNTP LHLAAAQSRS 120
DVISFLLSQK SINDCVKNKA HQQPLDMCKD LNVAQMIQLK RDDYFLETVH SLRAAMNKRD 180
FSKLDSIWKN PRNLNLLDIN GIDPETGTTL LYEYSQKKDI EMCQWLLKHG AEATVKDGKG 240
RSPLDLVKNI KLPAKPSNNV TPEIKLKNLL EKNLREQAIV HEDVASSKPP TYKGFLKKWT 300
NFAHGYKLRW FILSGDGNLS YYKDQSHVDR PRGTLKVSTC RLHIDSSEKL NFELLGGITG 360
TTRWRLKGNH PIETTRWVNA IQSAIRFAKD KEILNKKKAV PPSLALKNKS PALISHSKTQ 420
GSLPEASQYY QHTLHKEVIQ PSSVSLYRRP SNNLSVVSSE IQLNDNLTES GKRFVSKMIE 480
NRLDGSKTPV GVHTGSALQR VRSSNTLKSN RSMQSGSGVA SPIDKVPNGA NLSQSNTTTG 540
STASLSDNNY IDNFEGDEAN SDDEEEDLGI NFDRDEEYIK AQYGPYKEKL DMYEQAISIE 600
LSSLIELIEQ EEPSPEVWLT IKKSLINTST IFGKLKDLTY KRDKRLVDMV SKQGDVNNVW 660
VQSVKELEME LSNKTERLAS IDKERRGLKK ILHKKLLESH ATAGNKESLE NDKEQESDTT 720
ASTLGQIAKF ISATKEEDEA SDADEFYDAA ELVDEVTELT EAHPEISTAA APKHAPPPVP 780
NETDNDSQYV QDEKSKIESN VEKTSQKFEK QNNLVTEDEP KTDQSLKNFK AEDKESQVKE 840
KTKEIASSVI GEKTIVAVTT VQKRKEEYLL KEGSYLGYED GIRKRLSMDK DDRPKISLWA 900
VLKSMVGKDM TRMTLPVTFN EPTSLLQRVA EDLEYSELLD QAATFEDSTL RTLYVAAFTA 960
SSYASTTKRV AKPFNPLLGE TFEYSRPDKQ YRFFTEQVSH HPPISATWTE SPRWDFWGES 1020
FVDTKFNGRS FNVKHLGLWH IKLRPNDNEK EELYTWKKPN NTVIGILIGN PQVDNHGEVN 1080
VVNHTTGDHC KLYFKARGWR SSGAYEITGE VYNKKKQKVW ILGGHWNEAI FAKKVVKDGD 1140
LSLEKTRTAA SAGNGPTDDG TKFLIWKAND RPEEPFNLTP FAITLNAPQP HLLPWLPPTD 1200
TRLRPDQRAM EDGRYDEAGD EKFRVEEKQR AARRKREENN LEYHPQWFVR DTHPITKAKY 1260
WRYTGKYWVK RRDHDLKDCG DIF 1284
Keyword

KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0445--Lipid transport
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000648--Oxysterol-bd
IPR018494--Oxysterol-bd_CS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS01013--OSBP
PS50003--PH_DOMAIN
Pfam

PF01237--Oxysterol_BP
PF00169--PH
Gene Ontology

GO:0005935--C:cellular bud neck
GO:0032541--C:cortical endoplasmic reticulum
GO:0005783--C:endoplasmic reticulum
GO:0005635--C:nuclear envelope
GO:0005886--C:plasma membrane
GO:0005545--F:1-phosphatidylinositol binding
GO:0008289--F:lipid binding
GO:0008142--F:oxysterol binding
GO:0015248--F:sterol transporter activity
GO:0006897--P:endocytosis
GO:0035621--P:ER to Golgi ceramide transport
GO:0006887--P:exocytosis
GO:0030011--P:maintenance of cell polarity
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0015918--P:sterol transport