dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016676
Uniprot Accession Q12449; AHA1_YEAST; D6VSJ8; Q02565; Q7LIE3;
Genbank Protein ID NP_010500.3;
Genbank Nucleotide ID NM_001180522.3;
Protein Name Hsp90 co-chaperone AHA1
Protein Synonyms/Alias Activator of Hsp90 ATPase protein 1;
Gene Name AHA1
Gene Synonyms/Alias YDR214W;YD8142.16;YD8142B.06;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
35LVGVEAGSVKDKKYAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
49AKIKSVSSIEGDCEVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
159NDIQVPESQVKSNYTdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
172YTRGNQKSSFTEIKDdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900; 25315811; 19547744
173TRGNQKSSFTEIKDSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20702584; 19366988; 22369663;
191PKKNALPSSTSTSAPcurated25315811
200TSTSAPVSSTNKVPQcurated25315811
Sequence
(Fasta)		MVVNNPNNWH WVDKNCIGWA KEYFKQKLVG VEAGSVKDKK YAKIKSVSSI EGDCEVNQRK 60
GKVISLFDLK ITVLIEGHVD SKDGSALPFE GSINVPEVAF DSEASSYQFD ISIFKETSEL 120
SEAKPLIRSE LLPKLRQIFQ QFGKDLLATH GNDIQVPESQ VKSNYTRGNQ KSSFTEIKDS 180
ASKPKKNALP SSTSTSAPVS STNKVPQNGS GNSTSIYLEP TFNVPSSELY ETFLDKQRIL 240
AWTRSAQFFN SGPKLETKEK FELFGGNVIS ELVSCEKDKK LVFHWKLKDW SAPFNSTIEM 300
TFHESQEFHE TKLQVKWTGI PVGEEDRVRA NFEEYYVRSI KLTFGFGAVL 351
Keyword

KW-0002--3D-structure
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0346--Stress response
Interpro

IPR013538--Activator_of_Hsp90_ATPase
IPR015310--AHSA1_N
IPR023393--START-like_dom
PROSITE
Pfam

PF09229--Aha1_N
PF08327--AHSA1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0001671--F:ATPase activator activity
GO:0051087--F:chaperone binding
GO:0034605--P:cellular response to heat
GO:0032781--P:positive regulation of ATPase activity
GO:0006457--P:protein folding