dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016666
Uniprot Accession Q12434; GDIR_YEAST; D6VRL3;
Genbank Protein ID NP_010146.1;
Genbank Nucleotide ID NM_001180195.1;
Protein Name Rho GDP-dissociation inhibitor
Protein Synonyms/Alias
Gene Name RDI1
Gene Synonyms/Alias YDL135C;D2175;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
5---MAEESTDFSQFEPhosphoGRID 2.0;curated19823750; 19795423; 22369663; 24961812
6--MAEESTDFSQFEEcurated24961812
9AEESTDFSQFEEERNcurated22369663; 24961812
27YKVSAKKTVDEYKNLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 18407956; 16381945; 23193290; 19779198;
40NLDAEDESLAKWKESdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 21177495; 21126336;
52KESLGLSSDVLPLEFdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22369663; 22817900
106RYKIKENSIYKLKIVcurated26040406
177FLARGNYSAVSKFIDcurated25315811
Sequence
(Fasta)		MAEESTDFSQ FEEERNNDQY KVSAKKTVDE YKNLDAEDES LAKWKESLGL SSDVLPLEFP 60
GDKRKVVVQK IQLLVNTEPN PITFDLTNEK TIKELASKRY KIKENSIYKL KIVFKVQHEI 120
ITGLRYVQYI KKAGIAVDKI DDHLGSYAPN TKTKPFYEVE LPESEAPSGF LARGNYSAVS 180
KFIDDDKTNH LTLNWGVEIV KK 203
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR014756--Ig_E-set
IPR000406--Rho_GDI
IPR024792--RhoGDI_domain
PROSITE
Pfam

PF02115--Rho_GDI
Gene Ontology

GO:0005935--C:cellular bud neck
GO:0005934--C:cellular bud tip
GO:0005829--C:cytosol
GO:0005096--F:GTPase activator activity
GO:0005094--F:Rho GDP-dissociation inhibitor activity
GO:0007015--P:actin filament organization
GO:0050790--P:regulation of catalytic activity
GO:0032889--P:regulation of vacuole fusion, non-autophagic
GO:0007264--P:small GTPase mediated signal transduction