dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016664
Uniprot Accession Q12432; EAF3_YEAST; D6W433;
Genbank Protein ID NP_015348.1;
Genbank Nucleotide ID NM_001184120.1;
Protein Name Chromatin modification-related protein EAF3
Protein Synonyms/Alias ESA1-associated factor 3;
Gene Name EAF3
Gene Synonyms/Alias YPR023C;YP9367.03C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
49PNDKPGGSSQATKEIdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
50NDKPGGSSQATKEIKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20190278; 19060867;
132QQKKKKLSTSLGGPSPhosphoGRID 2.019779198
150KRKGDSRSNASISKScurated25315811
157SNASISKSTSQSFLTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988
159ASISKSTSQSFLTSSPhosphoGRID 2.0;PHOSIDA;curated19823750; 19779198; 19795423; 21081558; 22369663; 22817900;
176GRKSGRSSANSLHPGcurated25315811
179SGRSSANSLHPGSSLcurated22817900; 19547744
201GNDDRRRSSSLSPNMPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 22817900
202NDDRRRSSSLSPNMLPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040406
203DDRRRSSSLSPNMLHPhosphoPep 2.019060867
Sequence
(Fasta)		MVDLEQEFAL GGRCLAFHGP LMYEAKILKI WDPSSKMYTS IPNDKPGGSS QATKEIKPQK 60
LGEDESIPEE IINGKCFFIH YQGWKSSWDE WVGYDRIRAY NEENIAMKKR LANEAKEAKK 120
SLLEQQKKKK LSTSLGGPSN GGKRKGDSRS NASISKSTSQ SFLTSSVSGR KSGRSSANSL 180
HPGSSLRSSS DQNGNDDRRR SSSLSPNMLH HIAGYPTPKI SLQIPIKLKS VLVDDWEYVT 240
KDKKICRLPA DVTVEMVLNK YEHEVSQELE SPGSQSQLSE YCAGLKLYFD KCLGNMLLYR 300
LERLQYDELL KKSSKDQKPL VPIRIYGAIH LLRLISVLPE LISSTTMDLQ SCQLLIKQTE 360
DFLVWLLMHV DEYFNDKDPN RSDDALYVNT SSQYEGVALG M 402
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
PF11717--Tudor-knot
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0032221--C:Rpd3S complex
GO:0006281--P:DNA repair
GO:0016573--P:histone acetylation
GO:0016575--P:histone deacetylation
GO:0060195--P:negative regulation of antisense RNA transcription
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter