dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0016663 | ||||||||
| Uniprot Accession | Q12429; DPH6_YEAST; D6VYD7; Q07261; | ||||||||
| Genbank Protein ID | NP_013244.1; | ||||||||
| Genbank Nucleotide ID | NM_001182030.1; | ||||||||
| Protein Name | Diphthine--ammonia ligase | ||||||||
| Protein Synonyms/Alias | Diphthamide synthase;Diphthamide synthetase; | ||||||||
| Gene Name | DPH6 | ||||||||
| Gene Synonyms/Alias | YLR143W;L3177; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MKFIALISGG KDSFYNIFHC LKNNHELIAL GNIYPKESEE QELDSFMFQT VGHDLIDYYS 60 KCIGVPLFRR SILRNTSNNV ELNYTATQDD EIEELFELLR TVKDKIPDLE AVSVGAILSS 120 YQRTRVENVC SRLGLVVLSY LWQRDQAELM GEMCLMSKDV NNVENDTNSG NKFDARIIKV 180 AAIGLNEKHL GMSLPMMQPV LQKLNQLYQV HICGEGGEFE TMVLDAPFFQ HGYLELIDIV 240 KCSDGEVHNA RLKVKFQPRN LSKSFLLNQL DQLPVPSIFG NNWQDLTQNL PKQQAKTGEQ 300 RFENHMSNAL PQTTINKTND KLYISNLQSR KSETVEKQSE DIFTELADIL HSNQIPRNHI 360 LSASLLIRDM SNFGKINKIY NEFLDLSKYG PLPPSRACVG SKCLPEDCHV QLSVVVDVKN 420 TGKEKINKNK GGLHVQGRSY WAPCNIGPYS QSTWLNDDAN QVSFISGQIG LVPQSMEILG 480 TPLTDQIVLA LQHFDTLCET IGAQEKLLMT CYISDESVLD SVIKTWAFYC SNMNHRSDLW 540 MDKSDDVEKC LVLVKISELP RGAVAEFGGV TCKRLIVDDN DSDKKEREEN DDVSTVFQKL 600 NLNIEGFHNT TVSAFGYNRN FITGFVDSRE ELELILEKTP KSAQITLYYN PKEIITFHHH 660 IGYYPVEKLF DYRGKEHRFG LHIRS 686 |
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| Keyword | KW-0067--ATP-binding |
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| Interpro | IPR002761--Diphthami_syn_dom |
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| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005737--C:cytoplasm |