dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016659
Uniprot Accession Q12420; SNU66_YEAST; D6W308;
Genbank Protein ID NP_014953.3;
Genbank Nucleotide ID NM_001183728.3;
Protein Name 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
Protein Synonyms/Alias
Gene Name SNU66
Gene Synonyms/Alias YOR308C;05667;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the U4/U6.U5 tri-snRNP particle, one of the building blocks of the spliceosome. Required for pre-mRNA splicing.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
125SSHESKRSSTLPRKGdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900
155SYNIEALSPKKDTILcurated24961812
168ILTLKESSIFDDTDScurated24961812
254TISAKPPTGKVKVNFcurated22817900; 19547744
263KVKVNFDSANNMSDEPhosphoGRID 2.0;PhosphoPep 2.0;curated19684113; 19060867; 26040289; 22369663; 22817900; 24961812;
268FDSANNMSDEDGGDFdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 20702584;
315VDEDESLSWMEEEQPcurated20377248
331TIINPRTSSNNELKGcurated25882841
332IINPRTSSNNELKGPdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 19060867; 19366988;
367ILKMREISNSIVVDEcurated24961812
369KMREISNSIVVDEKVdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812
458LGYLRKKSVFTTGDVcurated24961812
489DVRNKEHTGTGTYTKPhosphoGRID 2.0;curated21177495; 22817900
491RNKEHTGTGTYTKDKPhosphoGRID 2.0;curated21177495; 22817900
494EHTGTGTYTKDKLHGPhosphoGRID 2.0;curated21177495; 22817900
575RIEARKNTPENGSLFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988; 22369663;
580KNTPENGSLFEFDDNPhosphoPep 2.0;curated19060867; 22817900; 24961812; 25521595
Sequence
(Fasta)		MNKTENLSIE ETNEIREKLG MKPIPVFQEK NTDHKESLSI EETNELRASL GLKLIPPQQN 60
FNSSPPNVHN TSKIDELREK ITKFQKKANA PLRMAHLLEE TNVNDDSSWL ENMDAIPSSH 120
ESKRSSTLPR KGATKEDENI DLHNVQVSYN IEALSPKKDT ILTLKESSIF DDTDSTEVLE 180
NVKAAEENAD REKLRLRQMN KDRRQKKKIL NVSSLDIEEE EEGEKHSITT THLIIGAEQG 240
VMKAPNTISA KPPTGKVKVN FDSANNMSDE DGGDFKPLKI KKRKIKDPRS TKARKSKITD 300
KMEIVKLVDE DESLSWMEEE QPVTIINPRT SSNNELKGPE DLAREIEKAR DEEKRRTESI 360
LKMREISNSI VVDEKVTFLN TLDTSLSERS ATENKVKVHG EGEKNIGDVT NGHTKEGSGN 420
NTLTEAVNNE PNYEGDAENA PNFFSGLAST LGYLRKKSVF TTGDVDLKPG KDVNNSESLR 480
RDVRNKEHTG TGTYTKDKLH GLEQFTSSDS SNANTHSKRQ DHYDPDIKLV YRDEKGNRLT 540
TKEAYKKLSQ KFHGTKSNKK KRAKMKSRIE ARKNTPENGS LFEFDDN 588
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0747--Spliceosome
Interpro

IPR005011--SNU66/SART1
PROSITE
Pfam

PF03343--SART-1
Gene Ontology

GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0000481--P:maturation of 5S rRNA
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000387--P:spliceosomal snRNP assembly