dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016657
Uniprot Accession Q12417; PRP46_YEAST; D6W3L8;
Genbank Protein ID NP_015174.1;
Genbank Nucleotide ID NM_001183965.1;
Protein Name Pre-mRNA-splicing factor PRP46
Protein Synonyms/Alias Complexed with CEF1 protein 1;PRP nineteen-associated complex protein 50;PRP19-associated complex protein 50;Pre-mRNA-processing protein 46;
Gene Name PRP46
Gene Synonyms/Alias CWC1;NTC50;YPL151C;P2594;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Involved in pre-mRNA splicing. May also be required for cell cycle progression at G2/M (By similarity).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
58YDTYRKESSSFSGEGdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
59DTYRKESSSFSGEGKcurated25315811
60TYRKESSSFSGEGKKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)
MDGNDHKVEN LGDVDKFYSR IRWNNQFSYM ATLPPHLQSE MEGQKSLLMR YDTYRKESSS 60
FSGEGKKVTL QHVPTDFSEA SQAVISKKDH DTHASAFVNK IFQPEVAEEL IVNRYEKLLS 120
QRPEWHAPWK LSRVINGHLG WVRCVAIDPV DNEWFITGSN DTTMKVWDLA TGKLKTTLAG 180
HVMTVRDVAV SDRHPYLFSV SEDKTVKCWD LEKNQIIRDY YGHLSGVRTV SIHPTLDLIA 240
TAGRDSVIKL WDMRTRIPVI TLVGHKGPIN QVQCTPVDPQ VVSSSTDATV RLWDVVAGKT 300
MKVLTHHKRS VRATALHPKE FSVASACTDD IRSWGLAEGS LLTNFESEKT GIINTLSINQ 360
DDVLFAGGDN GVLSFYDYKS GHKYQSLATR EMVGSLEGER SVLCSTFDKT GLRLITGEAD 420
KSIKIWKQDE TATKESEPGL AWNPNLSAKR F 452
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0005681--C:spliceosomal complex
GO:0000398--P:mRNA splicing, via spliceosome