dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016655
Uniprot Accession Q12415; TFC7_YEAST; D6W2G9; Q07347; Q6B220;
Genbank Protein ID NP_014753.1;
Genbank Nucleotide ID NM_001183529.1;
Protein Name Transcription factor tau 55 kDa subunit
Protein Synonyms/Alias TFIIIC 55 kDa subunit;Transcription factor C subunit 7;
Gene Name TFC7
Gene Synonyms/Alias YOR110W;O3234;YOR3234w;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
224IDETDDQTSFTYIPFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 25521595
225DETDDQTSFTYIPFSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 26040289;
279RQMTKKTSSPIPEADdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
280QMTKKTSSPIPEADDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
339GNRLYEGSWERLVGTcurated22369663
360AAHVHKKTAGLLSPTPhosphoGRID 2.0;PhosphoPep 2.021126336; 19060867
365KKTAGLLSPTEENETdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17330950; 18407956; 16381945; 23193290; 19823750;
367TAGLLSPTEENETTNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19823750; 19795423; 19366988;
417GDKEEVQSEKIYRIKcurated25315811
Sequence
(Fasta)		MVVNTIYIAR HGYRSNWLPE GPYPDPLTGI DSDVPLAEHG VQQAKELAHY LLSLDNQPEA 60
AFASPFYRCL ETVQPIAKLL EIPVYLERGI GEWYRPDRKP VIPVPAGYEI LSKFFPGVIS 120
QEWDSTLTPN EKGETEQEMY MRFKKFWPLF IERVEKEYPN VECILLVTHA ASKIALGMSL 180
LGYDNPRMSL NENGDKIRSG SCSLDKYEIL KKSYDTIDET DDQTSFTYIP FSDRKWVLTM 240
NGNTEFLSSG EEMNWNFDCV AEAGSDADIK KRQMTKKTSS PIPEADDQTE VETVYISVDI 300
PSGNYKERTE IAKSAILQYS GLETDAPLFR IGNRLYEGSW ERLVGTELAF PNAAHVHKKT 360
AGLLSPTEEN ETTNAGQSKG SSTANDPNIQ IQEEDVGLPD STNTSRDHTG DKEEVQSEKI 420
YRIKERIVLS NVRPM 436
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR014623--Tfc7/tau55
IPR019481--TFIIIC_tau55-rel
PROSITE
Pfam

PF00300--His_Phos_1
PF10419--TFIIIC_sub6
Gene Ontology

GO:0000127--C:transcription factor TFIIIC complex
GO:0003677--F:DNA binding
GO:0016791--F:phosphatase activity
GO:0042791--P:5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0016311--P:dephosphorylation
GO:0006359--P:regulation of transcription from RNA polymerase III promoter
GO:0000999--P:RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
GO:0001021--P:RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
GO:0001041--P:transcription from a RNA polymerase III hybrid type promoter
GO:0001009--P:transcription from RNA polymerase III type 2 promoter