dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016651
Uniprot Accession Q12406; ARP7_YEAST; D6W444;
Genbank Protein ID NP_015359.1;
Genbank Nucleotide ID NM_001184131.1;
Protein Name Actin-related protein 7
Protein Synonyms/Alias Actin-like protein ARP7;Chromatin structure-remodeling complex protein ARP7;SWI/SNF complex component ARP7;
Gene Name ARP7
Gene Synonyms/Alias SWP61;YPR034W;YP9367.14;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP7 and ARP9 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
273QMDQQLQYTALTGSPcurated26040406
279QYTALTGSPNNPLVQcurated22369663
336LGPLMAKSVKKAGAScurated22817900
343SVKKAGASINSMKANcurated22817900
470LKRDRKQSQATNATNPhosphoGRID 2.020190278
Sequence
(Fasta)
MTLNRKCVVI HNGSHRTVAG FSNVELPQCI IPSSYIKRTD EGGEAEFIFG TYNMIDAAAE 60
KRNGDEVYTL VDSQGLPYNW DALEMQWRYL YDTQLKVSPE ELPLVITMPA TNGKPDMAIL 120
ERYYELAFDK LNVPVFQIVI EPLAIALSMG KSSAFVIDIG ASGCNVTPII DGIVVKNAVV 180
RSKFGGDFLD FQVHERLAPL IKEENDMENM ADEQKRSTDV WYEASTWIQQ FKSTMLQVSE 240
KDLFELERYY KEQADIYAKQ QEQLKQMDQQ LQYTALTGSP NNPLVQKKNF LFKPLNKTLT 300
LDLKECYQFA EYLFKPQLIS DKFSPEDGLG PLMAKSVKKA GASINSMKAN TSTNPNGLGT 360
SHINTNVGDN NSTASSSNIS PEQVYSLLLT NVIITGSTSL IEGMEQRIIK ELSIRFPQYK 420
LTTFANQVMM DRKIQGWLGA LTMANLPSWS LGKWYSKEDY ETLKRDRKQS QATNATN 478
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR004000--Actin
IPR029911--Arp7_fungi

PROSITE
Pfam

PF00022--Actin

Gene Ontology

GO:0005634--C:nucleus
GO:0016586--C:RSC complex
GO:0016514--C:SWI/SNF complex
GO:0005198--F:structural molecule activity
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0006325--P:chromatin organization
GO:0006337--P:nucleosome disassembly
GO:0042766--P:nucleosome mobilization
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter