dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0016645 | ||||||||
| Uniprot Accession | Q12395; DCN1_YEAST; D6VYC3; | ||||||||
| Genbank Protein ID | NP_013229.1; | ||||||||
| Genbank Nucleotide ID | NM_001182015.1; | ||||||||
| Protein Name | Defective in cullin neddylation protein 1 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | DCN1 | ||||||||
| Gene Synonyms/Alias | YLR128W;L3111; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSNNKIKRKD ASPEQEAIES FTSLTKCDPK VSRKYLQRNH WNINYALNDY YDKEIGTFTD 60 EVSTVAHPPV YPKELTQVFE HYINNNLFDI DSLVKFIEEL GYNLEDLATL CLAHLLGYKK 120 LEEPLKREDF LSTWFMQGCS TISDMQECIK TLDVKLHEDL QYFTQIYNYA FNLILDPNRK 180 DIDTDEGIQY WKLFFQPEYP VRMEPDLLEA WFRFLRDEGK TTISKDTWRM LLLFFKRYPT 240 IQKIISDYDE TAAWPFIIDE FYECLQDQQ |
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| Keyword | KW-0002--3D-structure |
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| Interpro | |||||||||
| PROSITE | PS51229--DCUN1 |
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| Pfam | PF03556--Cullin_binding |
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| Gene Ontology | GO:0000151--C:ubiquitin ligase complex |