dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016640
Uniprot Accession Q12385; ICT1_YEAST; D6VY99; Q7LGX2;
Genbank Protein ID NP_013200.1;
Genbank Nucleotide ID NM_001181986.1;
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase ICT1
Protein Synonyms/Alias Increased copper tolerance protein 1;Lysophosphatidic acid acyltransferase ICT1;LPAAT;
Gene Name ICT1
Gene Synonyms/Alias YLR099C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
348EHDWMDKYAGYLTTEcurated26040406
351WMDKYAGYLTTESMLcurated26040406
353DKYAGYLTTESMLKNcurated26040406
354KYAGYLTTESMLKNKcurated26040406
356AGYLTTESMLKNKAKcurated26040406
Sequence
(Fasta)
MWTNTFKWCS KTEKETTTAD AKVCASVQGL KALQQQIMDS TTVRGSVNNT MTPGGINQWH 60
FHNKRANKVC TPTVLIHGYA ASSMAFYRTF ENLSDNIKDL YAIDLPANGA SEAPALQVNK 120
TKKIKSLRFK HIEDDVVIPV IEKRPPAEDI KSHLEQYESY FVDRIEQWRK DNKLRKINVV 180
GHSFGGYISF KYALKYPDSI EKLCLISPLG VENSIHAITH KWEPNTTYPL TFTDPSSRYY 240
TRKLNVPRFI FENQLNVLKW MGPIGSKLCS NYISTAYVKV PDQIYKDYLL HSFVGKNQTV 300
QPQTIKVFTH LFERNLIARD PIINNVRFLN PATPVMFMYG EHDWMDKYAG YLTTESMLKN 360
KAKASYVEVP DAGHNLFLDN PQHFASSLVS FLSK 395
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0594--Phospholipid biosynthesis
KW-1208--Phospholipid metabolism
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase

Interpro

IPR029058--AB_hydrolase
IPR000073--AB_hydrolase_1

PROSITE
Pfam

PF00561--Abhydrolase_1

Gene Ontology

GO:0003841--F:1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016787--F:hydrolase activity
GO:0042171--F:lysophosphatidic acid acyltransferase activity
GO:0006654--P:phosphatidic acid biosynthetic process