dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016638
Uniprot Accession Q12382; DGK1_YEAST; D6W310;
Genbank Protein ID NP_014956.3;
Genbank Nucleotide ID NM_001183731.3;
Protein Name CTP-dependent diacylglycerol kinase 1
Protein Synonyms/Alias Diglyceride kinase 1;DAG kinase 1;High-copy suppressor of SLY1 defect protein 1;
Gene Name DGK1
Gene Synonyms/Alias HSD1;YOR311C;O6111;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in pre-tRNA splicing (By similarity). CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PAH1/SMP2. Involved in the resistance to nickel chloride and nalidixic acid. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
3-----MGTEDAIALPPhosphoGRID 2.021126336
36HQVSAKVTIPAKEEIPhosphoGRID 2.0;curated19823750; 19795423; 22817900
44IPAKEEISSSDDDAHdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19684113; 19779198; 21081558;
45PAKEEISSSDDDAHVdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19684113; 19823750; 19779198;
46AKEEISSSDDDAHVPdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19684113; 19823750; 19779198;
55DDAHVPVTEIHLKSHPhosphoPep 2.0;curated19060867; 22817900
87HSSIGFITLYLYTQGcurated23607784
91GFITLYLYTQGINYKcurated23607784
92FITLYLYTQGINYKNcurated23607784
97LYTQGINYKNVLWPLcurated23607784
Sequence
(Fasta)		MGTEDAIALP NSTLEPRTEA KQRLSSKSHQ VSAKVTIPAK EEISSSDDDA HVPVTEIHLK 60
SHEWFGDFIT KHEIPRKVFH SSIGFITLYL YTQGINYKNV LWPLIYAFII LFILDLIRLN 120
WPFFNMLYCR TVGALMRKKE IHTYNGVLWY ILGLIFSFNF FSKDVTLISL FLLSWSDTAA 180
ATIGRKYGHL TPKVARNKSL AGSIAAFTVG VITCWVFYGY FVPAYSYVNK PGEIQWSPET 240
SRLSLNMLSL LGGVVAALSE GIDLFNWDDN FTIPVLSSLF MNAVIKTFKK 291
Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0460--Magnesium
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro
PROSITE
Pfam
Gene Ontology

GO:0000139--C:Golgi membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0031965--C:nuclear membrane
GO:0004143--F:diacylglycerol kinase activity
GO:0006654--P:phosphatidic acid biosynthetic process
GO:0016192--P:vesicle-mediated transport