dbPAF Protein Information
Tag | Content | ||||||||
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dbPAF ID | dbPAF-0016636 | ||||||||
Uniprot Accession | Q12379; SWM1_YEAST; D6VSP0; | ||||||||
Genbank Protein ID | NP_010546.1; | ||||||||
Genbank Nucleotide ID | NM_001180568.1; | ||||||||
Protein Name | Anaphase-promoting complex subunit SWM1 | ||||||||
Protein Synonyms/Alias | Anaphase-promoting complex subunit 13;Spore wall maturation protein 1; | ||||||||
Gene Name | SWM1 | ||||||||
Gene Synonyms/Alias | APC13;YDR260C;YD9320A.11;YD9320A.11c; | ||||||||
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
NCBI Taxa ID | 559292 | ||||||||
Functional Description (View all) |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. SWM1 is required for APC/C activity in meiosis. | ||||||||
Phosphorylation Sites |
dbPAF PTMs: 1
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Sequence (Fasta) | MSSSSYRDSY FQYRHLPAPH HILYAEWNQD ILALPDEVAN ITMAMKDNTR TDAEEGRAPQ 60 DGERNSNVRE SAQGKALMTS EQNSNRYWNS FHDEDDWNLF NGMELESNGV VTFAGQAFDH 120 SLNGGTNSRN DGANEPRKET ITGSIFDRRI TQLAYARNNG WHELALPQSR 171 |
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Keyword | KW-0131--Cell cycle |
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Interpro | IPR008401--Apc13p |
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PROSITE | |||||||||
Pfam | PF05839--Apc13p |
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Gene Ontology | GO:0005680--C:anaphase-promoting complex |