dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016628
Uniprot Accession Q12363; WTM1_YEAST; D6W2T4; O00041;
Genbank Protein ID NP_014873.3;
Genbank Nucleotide ID NM_001183649.3;
Protein Name Transcriptional modulator WTM1
Protein Synonyms/Alias
Gene Name WTM1
Gene Synonyms/Alias YOR230W;YOR50-20;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2-RNR4 in the nucleus.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
8MPKKVWKSSTPSTYEPhosphoPep 2.019060867
9PKKVWKSSTPSTYEHcurated25315811
10KKVWKSSTPSTYEHIdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 17330950; 21177495;
37NVLHQRKSLTFSNVVcurated22817900; 19823750; 24961812; 25315811
39LHQRKSLTFSNVVVPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
41QRKSLTFSNVVVPDKPhosphoPep 2.019060867
79VPLQEAASEPVKDYGdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
96FEGIENTSLSPKFVYcurated22369663; 19823750; 25521595; 25315811
98GIENTSLSPKFVYQGPhosphoGRID 2.0;PHOSIDA;curated19823750; 19795423; 21081558; 22369663; 22817900; 24961812;
107KFVYQGETVSKMAYLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
130LSMSKNGSLAWFKEGcurated22369663; 25315811
154ELMGPATSYASIHSLcurated24961812
162YASIHSLTRPGDLPEPHOSIDA;curated21081558; 19795423
187GISNDTETIVKSQSNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
193ETIVKSQSNGDEEDSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
200SNGDEEDSILKIIDNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 25315811
370SKYNPDDTIAPPQDAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22817900; 24961812
406KQIGRRNTAAWHPVIUniProt;curated19779198; 26040406; 22369663; 22817900
436YKPYTEESE------PHOSIDA;curated21081558; 19795423; 24961812
Sequence
(Fasta)		MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN NTLTSSVIYS 60
QGSDIYEIDF AVPLQEAASE PVKDYGDAFE GIENTSLSPK FVYQGETVSK MAYLDKTGET 120
TLLSMSKNGS LAWFKEGIKV PIHIVQELMG PATSYASIHS LTRPGDLPEK DFSLAISDFG 180
ISNDTETIVK SQSNGDEEDS ILKIIDNAGK PGEILRTVHV PGTTVTHTVR FFDNHIFASC 240
SDDNILRFWD TRTSDKPIWV LGEPKNGKLT SFDCSQVSNN LFVTGFSTGI IKLWDARAAE 300
AATTDLTYRQ NGEDPIQNEI ANFYHAGGDS VVDVQFSATS SSEFFTVGGT GNIYHWNTDY 360
SLSKYNPDDT IAPPQDATEE SQTKSLRFLH KGGSRRSPKQ IGRRNTAAWH PVIENLVGTV 420
DDDSLVSIYK PYTEESE 438
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003714--F:transcription corepressor activity
GO:0051457--P:maintenance of protein location in nucleus
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0010674--P:negative regulation of transcription from RNA polymerase II promoter during meiosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006606--P:protein import into nucleus
GO:0006351--P:transcription, DNA-templated