dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016626
Uniprot Accession Q12361; GPR1_YEAST; D6VRV9;
Genbank Protein ID NP_010249.1;
Genbank Nucleotide ID NM_001180094.1;
Protein Name G protein-coupled receptor GPR1
Protein Synonyms/Alias
Gene Name GPR1
Gene Synonyms/Alias YDL035C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth. It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
369IPTLFRKTNTGSDENdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 21126336; 19779198; 19060867;
371TLFRKTNTGSDENVSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 19779198; 19060867; 22817900
373FRKTNTGSDENVSASdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19779198; 19060867;
378TGSDENVSASGGVRLPhosphoPep 2.0;curated19060867; 22817900
477YDNKNDNSDITSNIKcurated25315811
481NDNSDITSNIKEKGGcurated26040289; 22369663; 22817900; 25315811
592NADRCENSSFTNVQQPhosphoPep 2.019060867
593ADRCENSSFTNVQQHPhosphoPep 2.0;curated19060867; 25315811
854NRLLKIRYNNDHFSLcurated22817900
860RYNNDHFSLPGLKFAPhosphoPep 2.0;curated19060867; 22817900; 24961812; 25315811
884HQDVSTNSMVKSSFFcurated26040289
903VTNDDENSIEEDKNLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19823750; 19795423;
Sequence
(Fasta)		MITEGFPPNL NALKGSSLLE KRVDSLRQLN TTTVNQLLGL PGMTSTFTAP QLLQLRIIAI 60
TASAVSLIAG CLGMFFLSKM DKRRKVFRHD LIAFLIICDF LKAFILMIYP MIILINNSVY 120
ATPAFFNTLG WFTAFAIEGA DMAIMIFAIH FAILIFKPNW KWRNKRSGNM EGGLYKKRSY 180
IWPITALVPA ILASLAFINY NKLNDDSDTT IILDNNNYNF PDSPRQGGYK PWSAWCYLPP 240
KPYWYKIVLS WGPRYFIIIF IFAVYLSIYI FITSESKRIK AQIGDFNHNV LEEEKEKKKL 300
FGLGHWGKAK WYFRSYFKLP LLHLLRNLKN FFTISFIDPN EETDDSGSSN GTFNFGESSN 360
EIPTLFRKTN TGSDENVSAS GGVRLLDYNS AKPLDMSKYA MSEQPDLERN NPFDCENDIT 420
LNPSELVSKQ KEHKVTFSVE NEGLDTRKSS MLGHQTFSCQ NSLESPLAMY DNKNDNSDIT 480
SNIKEKGGII NNNSNNDDDD NNNNNDNDND NNNSNNNNNN NNNNNNNNNN NNNNNNNNNN 540
NNNNSNNIKN NVDNNNTNPA DNIPTLSNEA FTPSQQFSQE RVNNNADRCE NSSFTNVQQH 600
FQAQTYKQMK KRRAQIQKNL RAIFIYPLSY IGIWLFPIIA DALQYNHEIK HGPTMWVTYI 660
DTCVRPLSCL VDVIVYLFKE KPWNYSWAKT ESKYLIEKYI LKGELGEKEI LKFCHSNWGK 720
RGWYYRGKWK KRKCWKYSTN PLKRILWFVE RFFKQLFELK LHFSFYDNCD DFEYWENYYS 780
AKDSNDNKRT ESDETKTNSS DRSLPSNSLE LQAMLNNITA EEVEVPLFWR IIHHIPMLGG 840
IDLDELNRLL KIRYNNDHFS LPGLKFALNQ NKSHDKHQDV STNSMVKSSF FSSNIVTNDD 900
ENSIEEDKNL RYSDASASEN YLVKPTIPGT TPDPIIEAQN DNDSSDSSGI DLIAFLRNGP 960
L 962
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR023041--Glucose_rcpt_Git3_N
IPR022596--GPR1_C
PROSITE
Pfam

PF11710--Git3
PF11970--Git3_C
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004930--F:G-protein coupled receptor activity
GO:0005536--F:glucose binding
GO:0051594--P:detection of glucose
GO:0009731--P:detection of sucrose stimulus
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0010255--P:glucose mediated signaling pathway
GO:0009757--P:hexose mediated signaling
GO:0001403--P:invasive growth in response to glucose limitation
GO:0007124--P:pseudohyphal growth
GO:0001302--P:replicative cell aging
GO:0009745--P:sucrose mediated signaling