dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0016622 | ||||||||||||
| Uniprot Accession | Q12354; APTH1_YEAST; D6VYB6; | ||||||||||||
| Genbank Protein ID | NP_013219.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001182005.1; | ||||||||||||
| Protein Name | Acyl-protein thioesterase 1 | ||||||||||||
| Protein Synonyms/Alias | |||||||||||||
| Gene Name | YLR118C | ||||||||||||
| Gene Synonyms/Alias | L2955; | ||||||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||||||
| NCBI Taxa ID | 559292 | ||||||||||||
| Functional Description (View all) |
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MNGLRVAAKI QPARQTIIFL HGLGDTGSGW GFLAQYLQQR DPAAFQHTNF VFPNAPELHV 60 TANGGALMPA WFDILEWDPS FSKVDSDGFM NSLNSIEKTV KQEIDKGIKP EQIIIGGFSQ 120 GAALALATSV TLPWKIGGIV ALSGFCSIPG ILKQHKNGIN VKTPIFHGHG DMDPVVPIGL 180 GIKAKQFYQD SCEIQNYEFK VYKGMAHSTV PDELEDLASF IKKSLSS 228 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | |||||||||||||
| PROSITE | |||||||||||||
| Pfam | PF02230--Abhydrolase_2 |
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| Gene Ontology | GO:0005737--C:cytoplasm |