dbPAF Protein Information
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dbPAF ID | dbPAF-0016618 | ||||||||||||||||||||||||||||||||||||||||
Uniprot Accession | Q12343; MED4_YEAST; D6W2N0; | ||||||||||||||||||||||||||||||||||||||||
Genbank Protein ID | NP_014817.3; | ||||||||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | NM_001183593.3; | ||||||||||||||||||||||||||||||||||||||||
Protein Name | Mediator of RNA polymerase II transcription subunit 4 | ||||||||||||||||||||||||||||||||||||||||
Protein Synonyms/Alias | Mediator complex subunit 4; | ||||||||||||||||||||||||||||||||||||||||
Gene Name | MED4 | ||||||||||||||||||||||||||||||||||||||||
Gene Synonyms/Alias | YOR174W;O3630; | ||||||||||||||||||||||||||||||||||||||||
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 559292 | ||||||||||||||||||||||||||||||||||||||||
Functional Description (View all) |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. | ||||||||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
dbPAF PTMs: 9
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Sequence (Fasta) | MSVQDTKAVE FSMGHIRSSS VSLVAEATSN TNSEDKLSKV QLYEDLCRYE DTLSKLVESV 60 DRFKPNLDIA KDLIRTDEAL FENVKLLAEY DNIYRNLQKI DKDSEELDSK TRKILEILNE 120 CHDELKALPM LEQVEFEKNT ILQQRSKINS TELLDYATKL SKFTKIPPTF DKGAVGPNNF 180 IWPAEDALRR GMLAMASLHS KELTRIPGEE VEETEVPTVP PSQSEEQKGQ MAKKEGTPKT 240 DSFIFDGTAK EVGDEADNTK DKEKEENNDD ALDLDLDLFD PDDF 285 |
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Keyword | KW-0007--Acetylation |
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Interpro | IPR019258--Mediator_Med4 |
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PROSITE | |||||||||||||||||||||||||||||||||||||||||
Pfam | PF10018--Med4 |
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Gene Ontology | GO:0070847--C:core mediator complex |