dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0016616 | ||||||||
| Uniprot Accession | Q12341; HAT1_YEAST; D6W411; Q6Q5I5; | ||||||||
| Genbank Protein ID | NP_015324.1; | ||||||||
| Genbank Nucleotide ID | NM_001183815.1; | ||||||||
| Protein Name | Histone acetyltransferase type B catalytic subunit | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | HAT1 | ||||||||
| Gene Synonyms/Alias | YPL001W;LPA16W;YP8132.12; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSANDFKPET WTSSANEALR VSIVGENAVQ FSPLFTYPIY GDSEKIYGYK DLIIHLAFDS 60 VTFKPYVNVK YSAKLGDDNI VDVEKKLLSF LPKDDVIVRD EAKWVDCFAE ERKTHNLSDV 120 FEKVSEYSLN GEEFVVYKSS LVDDFARRMH RRVQIFSLLF IEAANYIDET DPSWQIYWLL 180 NKKTKELIGF VTTYKYWHYL GAKSFDEDID KKFRAKISQF LIFPPYQNKG HGSCLYEAII 240 QSWLEDKSIT EITVEDPNEA FDDLRDRNDI QRLRKLGYDA VFQKHSDLSD EFLESSRKSL 300 KLEERQFNRL VEMLLLLNNS PSFELKVKNR LYIKNYDALD QTDPEKAREA LQNSFILVKD 360 DYRRIIESIN KSQG 375 |
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| Keyword | KW-0002--3D-structure |
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| Interpro | IPR016181--Acyl_CoA_acyltransferase |
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| PROSITE | PS51186--GNAT |
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| Pfam | |||||||||
| Gene Ontology | GO:0005737--C:cytoplasm |