| Tag |
Content |
| dbPAF ID |
dbPAF-0016603 |
| Uniprot Accession |
Q12315; GLE1_YEAST; D6VRE7;
|
| Genbank Protein ID |
NP_010074.1;
|
| Genbank Nucleotide ID |
NM_001180267.1;
|
| Protein Name |
Nucleoporin GLE1 |
| Protein Synonyms/Alias |
Nuclear pore protein GLE1;RNA export factor GLE1; |
| Gene Name |
GLE1 |
| Gene Synonyms/Alias |
BRR3;RSS1;YDL207W;D1049; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonuleoprotein (hnRNP) NAB2 from exported mRNA.Functional Description
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonuleoprotein (hnRNP) NAB2 from exported mRNA. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MRFVFDEVFN SDTDSPEFEE TCSTTSSTSS QCPTPEPSPA IKLPSFTKVG TKKLVNESVV 60
ILDPALENAL RDLNLQSKLI PINEPIVAAS SIIVPHSTNM PLPRASHSSL LDNAKNSNAT 120
APLLEAIEES FQRKMQNLVL ANQKEIQSIR ENKRRVEEQR KRKEEEERKR KEAEEKAKRE 180
QELLRQKKDE EERKRKEAEA KLAQQKQEEE RKKIEEQNEK ERQLKKEHEA KLLQQKDKLG 240
KAVTNFDKIS KMFWHYKDKI AQIKQDIVLP IKKADVNVRN LLSRHKRKIN PKFGQLTNSN 300
QQLFKIQNEL TQLINDTKGD SLAYHWILNF IAKAVVHQAE TEVRVKPESA LPLGKLTLYL 360
LVQFPELQEL FMARLVKKCP FVIGFTCEID TEKGRQNMGW KRNNENKWED NTSYDERMGG 420
ILSLFAIITR LQLPQEFITT TSHPFPIALS WHILARICNT PLNLITNTHF VILGSWWDAA 480
AVQFLQAYGN QASKLLILIG EELTSRMAEK KYVGAARLRI LLEAWQNNNM ESFPEMSP
539Fasta Sequence
>Q12315|GLE1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MRFVFDEVFNSDTDSPEFEETCSTTSSTSSQCPTPEPSPAIKLPSFTKVGTKKLVNESVVILDPALENALRDLNLQSKLIPINEPIVAASSIIVPHSTNMPLPRASHSSLLDNAKNSNATAPLLEAIEESFQRKMQNLVLANQKEIQSIRENKRRVEEQRKRKEEEERKRKEAEEKAKREQELLRQKKDEEERKRKEAEAKLAQQKQEEERKKIEEQNEKERQLKKEHEAKLLQQKDKLGKAVTNFDKISKMFWHYKDKIAQIKQDIVLPIKKADVNVRNLLSRHKRKINPKFGQLTNSNQQLFKIQNELTQLINDTKGDSLAYHWILNFIAKAVVHQAETEVRVKPESALPLGKLTLYLLVQFPELQELFMARLVKKCPFVIGFTCEIDTEKGRQNMGWKRNNENKWEDNTSYDERMGGILSLFAIITRLQLPQEFITTTSHPFPIALSWHILARICNTPLNLITNTHFVILGSWWDAAAVQFLQAYGNQASKLLILIGEELTSRMAEKKYVGAARLRILLEAWQNNNMESFPEMSP
|
| Keyword |
KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0507--mRNA processing
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport
|
| Interpro |
IPR012476--GLE1
|
| PROSITE |
|
| Pfam |
PF07817--GLE1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044614--C:nuclear pore cytoplasmic filaments
GO:0008047--F:enzyme activator activity
GO:0000822--F:inositol hexakisphosphate binding
GO:0005543--F:phospholipid binding
GO:0031369--F:translation initiation factor binding
GO:0006406--P:mRNA export from nucleus
GO:0006397--P:mRNA processing
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0043085--P:positive regulation of catalytic activity
GO:0015031--P:protein transport
GO:0006446--P:regulation of translational initiation
GO:0006449--P:regulation of translational termination
|
