dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016600
Uniprot Accession Q12310; PRR2_YEAST; D6VRE0;
Genbank Protein ID NP_010067.1;
Genbank Nucleotide ID NM_001180274.1;
Protein Name Serine/threonine-protein kinase PRR2
Protein Synonyms/Alias Pheromone response regulator 2;
Gene Name PRR2
Gene Synonyms/Alias YDL214C;D1014;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
57TGEALNKSYDSVFSSPhosphoGRID 2.020489023
63KSYDSVFSSLPVADSPhosphoGRID 2.020489023
64SYDSVFSSLPVADSVPhosphoGRID 2.020489023
112ENISKIDSNIISSPMPhosphoGRID 2.020489023
138KGRLRKNSTDFTSSFPhosphoGRID 2.020489023
150SSFSNSLSLPKSYGKPhosphoGRID 2.020489023
231MFTTRVYSLEDSVSSPhosphoGRID 2.020489023
Sequence
(Fasta)
MSLSRILRYN QRNNKTTASL TAEHAYSDNW AYSVSLGDPT SVGVNMAAKT GEALNKSYDS 60
VFSSLPVADS VPRTDFTASS RDDENTDVQK LTTSWMEKID TKMPENISKI DSNIISSPMV 120
SKVEARFIVP KGRLRKNSTD FTSSFSNSLS LPKSYGKLIF FTSKKNSSST KKNLANDISD 180
NKHNNNSSNT IGHNIPVTTA TATCDEIACT STEHEYNVYE EERMFTTRVY SLEDSVSSLS 240
TNPLDDTYSE AVQVNTRHIE DTESTAHIRK HSYTTSLSSI KRLFKITSFS NNNSNSCDHQ 300
ESTVADDCAI SSSLKETTSS PVSTGSFSLM IENEDSDRDQ IIQALYSNIE ASTDLVSRKY 360
RDLDVVLGEG SGGKVKLVQR VLDNKVFALK EYRSKKKRES ERKYIKNIIS EYCIASTLKN 420
PNICETLEIL YEKGKIFQIL EYCEYDLFSL VMSEKMHYEE ICCLFKQLIN GVKYLHDIGL 480
SHRDLKLDNC VVTRRGILKL IDFGASSVFH YPLSSQMIEA NGIVGSDPYL SPEVFYFNEY 540
DPRALDVWSV GIIFFCMITR RFPWKYPKVK DVQFKAFCSG RGVSSFKDLV TRPATDDSNN 600
YDNDGYEEGV IDMGPNFILH RLPEETHKIM RRILEVSPFR RITINGILQD GWIKEIETCQ 660
VVGAASPNEA SLRIINKGNH IHTNIDQRYA HIGGLHQRT
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0589--Pheromone response
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0035556--P:intracellular signal transduction
GO:0031138--P:negative regulation of conjugation with cellular fusion
GO:0046020--P:negative regulation of transcription from RNA polymerase II promoter by pheromones