dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016596
Uniprot Accession Q12297; TAF3_YEAST; D6W401;
Genbank Protein ID NP_015314.1;
Genbank Nucleotide ID NM_001183825.1;
Protein Name Transcription initiation factor TFIID subunit 3
Protein Synonyms/Alias TAFII-47;TAFII47;TBP-associated factor 3;TBP-associated factor 47 kDa;
Gene Name TAF3
Gene Synonyms/Alias TAF47;YPL011C;LPA6C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
237DRMPSAMTPRDEDALdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
280FEDEELESLGEVEGPcurated20377248
291VEGPNQKSQENNNEEcurated25704821; 25315811
299QENNNEESFKENNKScurated24961812; 25315811
308KENNKSLTESPHGDDPhosphoPep 2.0;curated19060867; 24961812; 20377248
310NNKSLTESPHGDDRDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 20702584; 19779198;
319HGDDRDISMFQFDSNPhosphoGRID 2.0;curated19779198; 22817900
345DSTFQRRTSLDYGGYPhosphoPep 2.0;curated19060867; 22369663
346STFQRRTSLDYGGYFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 18407956; 16381945; 23193290; 20702584; 19779198;
Sequence
(Fasta)		MTTNNDFYFA LLRISILQLL KAQGFDRARP SLVDVMTDLY AKFLSLLASE VSSIAQARCD 60
QDDTIALQDI TLALENLGIV KPTNVLDVYD ENSELSSSRG MEKFKDWCIY STQLTDARIT 120
ALPTVELLQS EEKESDPLSA IPDYLNQLLQ NKGAKQKLET KNRKTELIED LINNNGLDDW 180
IKLVIARQRI NMIERASKKE SQNVPALPHI AGYKSSILSR HHHTTITNED RMPSAMTPRD 240
EDALTEIQEN PFVTSKLPIM RKENRLENIT LSFEDEELES LGEVEGPNQK SQENNNEESF 300
KENNKSLTES PHGDDRDISM FQFDSNVDTK WAEQEDMDST FQRRTSLDYG GYF 354
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR006565--BTP
PROSITE
Pfam

PF07524--Bromo_TP
Gene Ontology

GO:0005669--C:transcription factor TFIID complex
GO:0003682--F:chromatin binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0006366--P:transcription from RNA polymerase II promoter