dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016589
Uniprot Accession Q12280; IQG1_YEAST; D6W3C9;
Genbank Protein ID NP_015082.1;
Genbank Nucleotide ID NM_001184056.1;
Protein Name Ras GTPase-activating-like protein IQG1
Protein Synonyms/Alias Cytokinesis protein 1;IQGAP-related protein 1;
Gene Name IQG1
Gene Synonyms/Alias CYK1;YPL242C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis. Seems to be involved in additional tasks during cell division like axial bud-site selection and targeted secretion by recruiting the spatial landmark BUD4, the septin CDC12 and the secretion landmark SEC3 to the bud neck. May be regulated by calcium ions.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
7-MTAYSGSPSKPGNNPhosphoPep 2.019060867
9TAYSGSPSKPGNNNSPhosphoPep 2.019060867
49NSSLNIASPSHLKTKPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 22817900; 25315811
51SLNIASPSHLKTKTSPhosphoPep 2.019060867
260RDFKSLGTNINTAPAPhosphoGRID 2.019779198
264SLGTNINTAPASPEEPhosphoGRID 2.0;UniProt;curated19779198; 22817900; 24961812
268NINTAPASPEEPKEKPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 22817900; 24961812
299PVEEILITPRKNITDUniProt;curated19779198; 22817900
310NITDANCSDFSNTPSPhosphoGRID 2.019779198
315NCSDFSNTPSPYNEAPhosphoGRID 2.0;curated19779198; 22817900
317SDFSNTPSPYNEAPKPhosphoGRID 2.019779198
338VVEKRKFTPIEPSLLcurated24961812
350SLLGPTPSLEYSPIKPhosphoPep 2.0;curated19060867; 24603354
353GPTPSLEYSPIKNKSPhosphoPep 2.019060867
354PTPSLEYSPIKNKSLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19779198; 19366988;
365NKSLSYYSPTISKYLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
401QTFKYSPSHYSPMRRPhosphoGRID 2.019779198
404KYSPSHYSPMRRERMPhosphoGRID 2.019779198
1347FQKAKDFSPVHKSKFcurated25315811
Sequence
(Fasta)		MTAYSGSPSK PGNNNSYLNR YVENLGTNVT PPLRPQSSSK INSSLNIASP SHLKTKTSAS 60
NSSATILSKK VESSVSKLKP SLPNKLVGKY TVDLSNYSKI ELRYYEFLCR VSEVKIWIEA 120
VIEEALPSEI ELCVGDSLRN GVFLAKLTQR INPDLTTVIF PAGDKLQFKH TQNINAFFGL 180
VEHVGVPDSF RFELQDLYNK KNIPQVFETL HILISMINKK WPGKTPALTN VSGQISFTKE 240
EIAACKKAWP RIRDFKSLGT NINTAPASPE EPKEKRSGLI KDFNKFERPN IPVEEILITP 300
RKNITDANCS DFSNTPSPYN EAPKMSNLDV VVEKRKFTPI EPSLLGPTPS LEYSPIKNKS 360
LSYYSPTISK YLTYDTEFYT RRSRAREEDL NYYQTFKYSP SHYSPMRRER MTEEQFLEKV 420
VQLQNICRGV NTRFNLYIQK RLLNLFEQDI LRFQACLRGN KFRVLSSMYL PIRRAKIDVP 480
HVEAIQSRIK GSRIRYKYDK LKFTLSRFSC TVELLQAYCR SKLLKTTVNT KLNDIEISHY 540
PLTKLQSYMR ASYVRKKVMS LNTKLNDERE SIMKFSAIIR GNVVRCSEDA ILSAVHDVHK 600
ENISKLQSLI RGIFTRSCLA SIIYSLGKEN CNIIQLSACI RGNAVRHKVQ SLFAPENNLS 660
ETVHDLQGLV RGILVRYTLD LVDDIVEYNN LALFQAFSRG ALVRESLDQK SSFYKRNVRS 720
VIMIQSWIRK SLQRSAYLEL LDCPNPSLWA VKKFVHLLNG TATIEEVQNQ LESCQASLDS 780
ENMKKERLLK SIRQQLNING VLDKFGLLKD KDHELGISDS TIPKSKYQKY EKLFYMLQVD 840
PSYWKLLYLK EPEFVAKNVY MTFGTVNQRM NDRERSYFTR FVCEMLQNAI NEAPSIESFL 900
DNRSQFWQTI LQDFLRRESP EFFSIIVPVL DYLSDPVVDF ESDPYKIYQE IHGFSSPQHC 960
SPVDDASTKN KFIDNLRCLW HAIEMVAEIY TRKVHTIPVE IRYLCTKIFC YAADKNIEEI 1020
DSLRAISSIL VNVFVSEYLV NREYYGYKDS NVQKNNQKID ILMKSLATVF EIKNFDGFLD 1080
PLNQYANEIK PHIKDVLYNV LVDPEYEQEG DRLIYLDMVS PSPKLELLTE KVLEISGKFE 1140
EYLNEFPEAD ILHDILEKNL DNSSFPRSGR VTLELDASAY RFLVSDDKMR KIYDQVKRAF 1200
VYMMQIEDVD TNLYDLSIST ILPQDEPNFA NFLEQNPKIR DDPMIQKLKP LKYFTLKNVT 1260
LKKIHELEST GTFCSSDNKL QNFLNDIANT IKNPNYAIDY VTQEIYITKE TLTKISEMNH 1320
SLDIELSRLK KHVDHTIKDF QKAKDFSPVH KSKFGNFKNA VKKVQGRERS ELQGMKFKWN 1380
TKQLYERGVL KTIRGEKLAE LTVKVFGSSG PKFPDIIFKI STSDGSRFGI QMIDKRKGPD 1440
KRYSDDVDSF SFKDLIKTQV EPKIETWKLF HSNVVVNNSQ LLHLIVSFFY KRNAL 1496
Keyword

KW-0009--Actin-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR001715--CH-domain
IPR000048--IQ_motif_EF-hand-BS
IPR000593--RasGAP_C
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
PROSITE

PS50021--CH
Pfam

PF00307--CH
PF00612--IQ
PF00616--RasGAP
PF03836--RasGAP_C
Gene Ontology

GO:0000142--C:cellular bud neck contractile ring
GO:0008092--F:cytoskeletal protein binding
GO:0005096--F:GTPase activator activity
GO:0007015--P:actin filament organization
GO:0007049--P:cell cycle
GO:0000920--P:cell separation after cytokinesis
GO:0006970--P:response to osmotic stress
GO:0007264--P:small GTPase mediated signal transduction