dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016584
Uniprot Accession Q12271; INP53_YEAST; D6W2G8;
Genbank Protein ID NP_014752.3;
Genbank Nucleotide ID NM_001183528.3;
Protein Name Polyphosphatidylinositol phosphatase INP53
Protein Synonyms/Alias Suppressor of PMA1 protein 2;Synaptojanin-like protein 3;
Gene Name INP53
Gene Synonyms/Alias SJL3;SOP2;YOR109W;YOR3231w;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN.
Phosphorylation Sites
 dbPAF PTMs: 28 (View all)
PositionPeptidesSourceReferences ( PMIDs )
340NLLSTKSSEIELSKRcurated25315811
489GTNALKSSFSRKGKMcurated22369663
896SLISDLLSLDLDNKSPhosphoGRID 2.0;curated20489023; 26040289; 22369663; 24961812
903SLDLDNKSTDGFKSSdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 24961812
932PTASSVASSSPVSSAdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
933TASSVASSSPVSSASdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
934ASSVASSSPVSSASAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
973PPPPAHKSVSAPAPSPhosphoGRID 2.0;curated21126336; 22369663; 23825934
975PPAHKSVSAPAPSTSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 19779198; 19366988;
981VSAPAPSTSKEKSPTPhosphoPep 2.019060867
986PSTSKEKSPTPQTSTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21177495; 20489023;
988TSKEKSPTPQTSTASdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 20702584; 19779198;
991EKSPTPQTSTASLSScurated22369663; 22817900
992KSPTPQTSTASLSSVcurated22369663; 22817900; 25315811; 20377248
993SPTPQTSTASLSSVTcurated22369663; 20377248
995TPQTSTASLSSVTKNcurated22369663; 22817900; 19823750; 20377248; 19547744
997QTSTASLSSVTKNIQcurated22369663
998TSTASLSSVTKNIQEcurated22369663
1026GFSQNILTPKSTSNLPhosphoPep 2.019060867
1029QNILTPKSTSNLASPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 25315811
Sequence
(Fasta)		MIIFVSEEPE RRLAIVSNLY ALVLKPVGKK PSDKPLCAIE LLQKNDLKKY GFKRLTSHEI 60
FGVIGLIEVN GLLFVGAITG KSKVAQPCPG ETVNKIFAVD FFCLNDNSWD FIEIDSSGYP 120
VLPETASTEY QDALPKHPCY ELKKLLSNGS FYYSSDFDLT STLQHRGYGQ HSLSTDTYEE 180
EYMWNSFLMQ EMITYRDHLD TNLKQILDDE GFLTTVIRGF AETFVSYVKK LKVALTIISK 240
QSWKRAGTRF NARGVDDEAN VANFVETEFI MYSSQYCYAF TQIRGSIPVF WEQGTSLINP 300
RVQITRSFEA TQPVFDKHIM KSVEKYGPVH VVNLLSTKSS EIELSKRYKE HLTHSKKLNF 360
NKDIFLTEFD FHKETSQEGF SGVRKLIPLI LDSLLSSGYY SYDVREKKNI SEQHGIFRTN 420
CLDCLDRTNL AQQIISLAAF RTFLEDFRLI SSNSFIDDDD FVSKHNTLWA DHGDQISQIY 480
TGTNALKSSF SRKGKMSLAG ALSDATKSVS RIYINNFMDK EKQQNIDTLL GRLPYQKAVQ 540
LYDPVNEYVS TKLQSMSDKF TSTSNINLLI GSFNVNGATK KVDLSKWLFP IGEKFKPDIV 600
VLGLQEVIEL SAGSILNADY SKSSFWENLV GDCLNQYDDK YLLLRVEQMT SLLILFFVKA 660
DKAKYVKQVE GATKKTGFRG MAGNKGAVSI RFEYGATSFC FVNSHLAAGA TNVEERRSDY 720
ESIVRGITFT RTKMIPHHDS IFWLGDMNYR INLPNEDVRR ELLNQEEGYI DKLLHFDQLT 780
LGINSGSVFE GFKEPTLKFR PTYKYDPGTG TYDSSEKERT PSWTDRIIYK GENLLPLSYS 840
DAPIMISDHR PVYAAYRAKI TFVDDKERLS LKKRLFTEYK QEHPEEPGSL ISDLLSLDLD 900
NKSTDGFKSS SESSLLDIDP IMAQPTASSV ASSSPVSSAS ASLQPVRTQN SSQSRTPIKK 960
PVLRPPPPPA HKSVSAPAPS TSKEKSPTPQ TSTASLSSVT KNIQENKPLA QNRRIPPPGF 1020
SQNILTPKST SNLASPMSSK VDLYNSASES TRSAQDARQQ TPTAFAASRD VNGQPEALLG 1080
DENPIEPEEK AKLNHMTLDS WQPLTPK 1108
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR005135--Endo/exonuclease/phosphatase
IPR000300--IPPc
IPR002013--SAC_dom
PROSITE

PS50275--SAC
Pfam

PF03372--Exo_endo_phos
PF02383--Syja_N
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0043813--F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0004438--F:phosphatidylinositol-3-phosphatase activity
GO:0004439--F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0043812--F:phosphatidylinositol-4-phosphate phosphatase activity
GO:0006897--P:endocytosis
GO:0046856--P:phosphatidylinositol dephosphorylation
GO:0036092--P:phosphatidylinositol-3-phosphate biosynthetic process
GO:0015031--P:protein transport