dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016583
Uniprot Accession Q12267; SMC4_YEAST; D6VY86;
Genbank Protein ID NP_013187.1;
Genbank Nucleotide ID NM_001181973.1;
Protein Name Structural maintenance of chromosomes protein 4
Protein Synonyms/Alias
Gene Name SMC4
Gene Synonyms/Alias YLR086W;L9449.5;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MSDSPLSKRQKcurated26040289
7-MSDSPLSKRQKRKScurated22817900
14SKRQKRKSAQEPELScurated25315811
21SAQEPELSLDQGDAEcurated25315811
31QGDAEEDSQVENRVNcurated25315811
40VENRVNLSENTPEPDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900
43RVNLSENTPEPDLPAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040289; 22817900;
105SRGRDHKSYSQSPPRPhosphoGRID 2.0;curated21177495; 22817900; 25315811
106RGRDHKSYSQSPPRSPhosphoGRID 2.0;curated21177495; 22817900
107GRDHKSYSQSPPRSPPhosphoGRID 2.0;curated21177495; 22369663; 22817900; 24961812
109DHKSYSQSPPRSPGRPhosphoGRID 2.0;curated21177495; 19779198; 26040289; 22369663; 22817900; 24961812;
113YSQSPPRSPGRSPTRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 19779198; 19060867;
117PPRSPGRSPTRRLELPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19779198; 19060867; 26040289; 22369663; 22817900;
119RSPGRSPTRRLELLQPhosphoGRID 2.0;curated21177495; 26040289; 22817900
128RLELLQLSPVKNSRVPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19779198; 19060867; 26040406; 26040289; 22369663;
147IYDRHQSSSKQQSRLcurated22817900
148YDRHQSSSKQQSRLFcurated22817900
152QSSSKQQSRLFINELcurated22817900
605EKILAKKTHKQELQDPhosphoGRID 2.0;curated19823750; 19795423; 22817900
623DLKKKLNSLKDERSQcurated22817900
Sequence
(Fasta)		MSDSPLSKRQ KRKSAQEPEL SLDQGDAEED SQVENRVNLS ENTPEPDLPA LEASYSKSYT 60
PRKLVLSSGE NRYAFSQPTN STTTSLHVPN LQPPKTSSRG RDHKSYSQSP PRSPGRSPTR 120
RLELLQLSPV KNSRVELQKI YDRHQSSSKQ QSRLFINELV LENFKSYAGK QVVGPFHTSF 180
SAVVGPNGSG KSNVIDSMLF VFGFRANKMR QDRLSDLIHK SEAFPSLQSC SVAVHFQYVI 240
DESSGTSRID EEKPGLIITR KAFKNNSSKY YINEKESSYT EVTKLLKNEG IDLDHKRFLI 300
LQGEVENIAQ MKPKAEKESD DGLLEYLEDI IGTANYKPLI EERMGQIENL NEVCLEKENR 360
FEIVDREKNS LESGKETALE FLEKEKQLTL LRSKLFQFKL LQSNSKLAST LEKISSSNKD 420
LEDEKMKFQE SLKKVDEIKA QRKEIKDRIS SCSSKEKTLV LERRELEGTR VSLEERTKNL 480
VSKMEKAEKT LKSTKHSISE AENMLEELRG QQTEHETEIK DLTQLLEKER SILDDIKLSL 540
KDKTKNISAE IIRHEKELEP WDLQLQEKES QIQLAESELS LLEETQAKLK KNVETLEEKI 600
LAKKTHKQEL QDLILDLKKK LNSLKDERSQ GEKNFTSAHL KLKEMQKVLN AHRQRAMEAR 660
SSLSKAQNKS KVLTALSRLQ KSGRINGFHG RLGDLGVIDD SFDVAISTAC PRLDDVVVDT 720
VECAQHCIDY LRKNKLGYAR FILLDRLRQF NLQPISTPEN VPRLFDLVKP KNPKFSNAFY 780
SVLRDTLVAQ NLKQANNVAY GKKRFRVVTV DGKLIDISGT MSGGGNHVAK GLMKLGTNQS 840
DKVDDYTPEE VDKIERELSE RENNFRVASD TVHEMEEELK KLRDHEPDLE SQISKAEMEA 900
DSLASELTLA EQQVKEAEMA YVKAVSDKAQ LNVVMKNLER LRGEYNDLQS ETKTKKEKIK 960
GLQDEIMKIG GIKLQMQNSK VESVCQKLDI LVAKLKKVKS ASKKSGGDVV KFQKLLQNSE 1020
RDVELSSDEL KVIEEQLKHT KLALAENDTN MNETLNLKVE LKEQSEQLKE QMEDMEESIN 1080
EFKSIEIEMK NKLEKLNSLL TYIKSEITQQ EKGLNELSIR DVTHTLGMLD DNKMDSVKED 1140
VKNNQELDQE YRSCETQDES EIKDAETSCD NYHPMNIDET SDEVSRGIPR LSEDELRELD 1200
VELIESKINE LSYYVEETNV DIGVLEEYAR RLAEFKRRKL DLNNAVQKRD EVKEQLGILK 1260
KKRFDEFMAG FNIISMTLKE MYQMITMGGN AELELVDSLD PFSEGVTFSV MPPKKSWRNI 1320
TNLSGGEKTL SSLALVFALH KYKPTPLYVM DEIDAALDFR NVSIVANYIK ERTKNAQFIV 1380
ISLRNNMFEL AQQLVGVYKR DNRTKSTTIK NIDILNRT 1419
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0226--DNA condensation
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR027417--P-loop_NTPase
IPR003395--RecF/RecN/SMC_N
IPR024704--SMC
IPR010935--SMC_hinge
PROSITE
Pfam

PF06470--SMC_hinge
PF02463--SMC_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000799--C:nuclear condensin complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0051301--P:cell division
GO:0006268--P:DNA unwinding involved in DNA replication
GO:0010032--P:meiotic chromosome condensation
GO:0051307--P:meiotic chromosome separation
GO:0007076--P:mitotic chromosome condensation
GO:0000070--P:mitotic sister chromatid segregation
GO:0070550--P:rDNA condensation
GO:0007130--P:synaptonemal complex assembly
GO:0070058--P:tRNA gene clustering