dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016581
Uniprot Accession Q12265; KPR5_YEAST; D6W206;
Genbank Protein ID NP_014580.1;
Genbank Nucleotide ID NM_001183316.1;
Protein Name Ribose-phosphate pyrophosphokinase 5
Protein Synonyms/Alias Phosphoribosyl pyrophosphate synthase 5;
Gene Name PRS5
Gene Synonyms/Alias PRPS5;YOL061W;O1213;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
119ISKPKENYTFESHPGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 19060867; 19366988;
120SKPKENYTFESHPGTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 21177495; 19779198; 19060867;
123KENYTFESHPGTPVSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
127TFESHPGTPVSSSLMdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
130SHPGTPVSSSLMTQRdbPTM 3.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 19366988; 22817900
131HPGTPVSSSLMTQRPPhosphoGRID 2.0;curated19779198; 20377248
132PGTPVSSSLMTQRPGPhosphoGRID 2.0;curated21177495; 22817900; 25315811; 20377248
135PVSSSLMTQRPGAEScurated22369663; 20377248
146GAESSLKSLDSAIRScurated22369663; 25315811
149SSLKSLDSAIRSTINcurated22369663; 22817900
153SLDSAIRSTINLENPcurated25315811
154LDSAIRSTINLENPQdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
165ENPQPIRTPNSSATAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
171RTPNSSATANNNFDIcurated22817900; 19547744
181NNFDIKKTLSFSRIPPhosphoGRID 2.0;curated19823750; 19779198; 19795423; 26040406; 22369663; 22817900;
183FDIKKTLSFSRIPMIdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17287358; 16381945; 23193290; 21177495; 20702584;
185IKKTLSFSRIPMIPGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 26040406; 22817900;
325PPDATLTSGGSLPVScurated20377248
328ATLTSGGSLPVSPRPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26447709; 25315811
332SGGSLPVSPRPLVTTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040289; 24961812;
Sequence
(Fasta)		MSMSNIVVFG GDSHPELVTK ICENLDIHPS KVELGKFSNG ETNIALRESV REKDVYIIQS 60
GCGQVNDTFM QLLILISACK SASASRVTAV MPYLCYSRQP DIPYTAKGAP IISKPKENYT 120
FESHPGTPVS SSLMTQRPGA ESSLKSLDSA IRSTINLENP QPIRTPNSSA TANNNFDIKK 180
TLSFSRIPMI PGGKLQNTSN STDAGELFNA QNAGYKLWVV QAGTLIAHLL SAAGADHVIT 240
MDLHDPQFPG FFDIPVDNLY CKPIAQNYIQ HRIPDYQDAV IVSPDAGGAK RATAIADALE 300
LSFALIHKER RSQLLKGPPD ATLTSGGSLP VSPRPLVTTL VSSQNTTSSG ATGVAALEMK 360
KTTSTSSTSS QSSNSSKFVQ TTMLVGDVRN KVCIIVDDLV DTSYTITRAA KLLKDQGSTK 420
VYALITHGVF SGDALERIGQ SSIDKLIISN TVPQDRTLQY LGKDRVDVID VSCIIGEAIR 480
RIHNGESISM LFEHGW 497
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0545--Nucleotide biosynthesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR000842--PRib_PP_synth_CS
IPR029099--Pribosyltran_N
IPR029057--PRTase-like
IPR005946--Rib-P_diPkinase
PROSITE

PS00114--PRPP_SYNTHASE
Pfam

PF14572--Pribosyl_synth
PF13793--Pribosyltran_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0002189--C:ribose phosphate diphosphokinase complex
GO:0005524--F:ATP binding
GO:0016301--F:kinase activity
GO:0000287--F:magnesium ion binding
GO:0004749--F:ribose phosphate diphosphokinase activity
GO:0006015--P:5-phosphoribose 1-diphosphate biosynthetic process
GO:0031505--P:fungal-type cell wall organization
GO:0009165--P:nucleotide biosynthetic process
GO:0009156--P:ribonucleoside monophosphate biosynthetic process