dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016559
Uniprot Accession Q12222; YGK3_YEAST; D6W1U0;
Genbank Protein ID NP_014513.1;
Genbank Nucleotide ID NM_001183382.1;
Protein Name Glycogen synthase kinase-3 homolog YGK3
Protein Synonyms/Alias
Gene Name YGK3
Gene Synonyms/Alias YOL128C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Required for heat stress-instigated phosphorylation of BCY1 which is involved in cell wall integrity signaling. Regulates activity of MSN2, a transcription factor that binds to the stress-response element (STRE). Probably promotes formation of a complex between MSN2 and DNA. Regulates the stability of ROG1.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
208DNTELKTYFCSRFYRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20702584; 19366988; 20377248
211ELKTYFCSRFYRAPEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900
276PKSSIKNSQELQDSLPhosphoGRID 2.020489023
282NSQELQDSLNDQKFKPhosphoGRID 2.020489023
Sequence
(Fasta)		MLKVNNVFGS NPNRMTKLED EHYFIDDIVS IKNRQKSKMY VREGKRIGHG SFGTVTQSIL 60
SSNSIEWLGP YAIKRVVKSP KVQSLELEIL QNIRHPNLVT LEFFFESHCT TKDGGHLYQK 120
NFVMEYIPQT LSSEIHEYFD NGSKMPTKHI KLYTFQILRA LLTLHSMSIC HGDLKPSNIL 180
IIPSSGIAKV CDFGSAQRLD DNTELKTYFC SRFYRAPELL LNSKDYTTQI DIWSLGCIIG 240
EMIKGQPLFK GDSANSQLEE IAKLLGRFPK SSIKNSQELQ DSLNDQKFKK FMHWFPSIEF 300
FDVEFLLKVL TYDATERCDA RQLMAHEFFD ALRNETYFLP RGSSMPVHLP DLFNFSASEK 360
RALGEYYNLI VPSLD 376
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0034605--P:cellular response to heat
GO:0071472--P:cellular response to salt stress
GO:0006468--P:protein phosphorylation
GO:0006508--P:proteolysis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated