dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016548
Uniprot Accession Q12208; USB1_YEAST; D6VYC7;
Genbank Protein ID NP_013233.1;
Genbank Nucleotide ID NM_001182019.1;
Protein Name U6 snRNA phosphodiesterase
Protein Synonyms/Alias U six biogenesis protein 1;
Gene Name USB1
Gene Synonyms/Alias YLR132C;L3127;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 3'phosphate. Could be involved in aerobic respiration.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
42CIQKADSTDLPAIPDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040406
Sequence
(Fasta)
MEFISADYSS SDGSDTESES SNKSEVQIEY TEKTCIQKAD STDLPAIPDS IILKYHIPPN 60
LQKYEHQDMN MSRFWRSFTY FEWRPTPAIH RQLQKIICKY KETFMKQEYT NPYQLVDFDP 120
LFISHLGAPK PLHVSLTRSL LFETEEQRHV FIQEMRNGLR NNEITPFKLQ ICSYPKLYIS 180
ERANTLYLGL PVSECPNKAQ ISPFKTIIAE ALQKSGISNY QDLIVSRQNL HVSIAIASNP 240
SKATLKRYQQ LNETMGALLL LNNDFAYKLE FLVNSIYCDE NRHSIRIPFN 291
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0496--Mitochondrion
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR027521--Usb1

PROSITE
Pfam

PF09749--HVSL

Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000175--F:3'-5'-exoribonuclease activity
GO:0008081--F:phosphoric diester hydrolase activity
GO:0006397--P:mRNA processing
GO:0090503--P:RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0008380--P:RNA splicing
GO:0034477--P:U6 snRNA 3'-end processing