dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016546
Uniprot Accession Q12206; WTM2_YEAST; D6W2T3;
Genbank Protein ID NP_014872.1;
Genbank Nucleotide ID NM_001183648.1;
Protein Name Transcriptional modulator WTM2
Protein Synonyms/Alias
Gene Name WTM2
Gene Synonyms/Alias YOR229W;YOR50-19;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Transcriptional modulator with roles in meiotic regulation and silencing.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
4----MAKSKSSQGAScurated19823750
7-MAKSKSSQGASGARcurated19823750
11SKSSQGASGARRKPAcurated19823750
45DVLHFSKTLTWRSEIPhosphoGRID 2.0;curated19823750; 19795423; 22817900
107EGNGKTKSAATPNPEcurated24603354; 23825934
110GKTKSAATPNPEYGDdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900; 24961812; 26447709;
420HTGGTRRSSNQFGKRcurated25315811
421TGGTRRSSNQFGKRNdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900; 25315811; 20377248
Sequence
(Fasta)		MAKSKSSQGA SGARRKPAPS LYQHISSFKP QFSTRVDDVL HFSKTLTWRS EIIPDKSKGT 60
LTTSLLYSQG SDIYEIDTTL PLKTFYDDDD DDDNDDDDEE GNGKTKSAAT PNPEYGDAFQ 120
DVEGKPLRPK WIYQGETVAK MQYLESSDDS TAIAMSKNGS LAWFRDEIKV PVHIVQEMMG 180
PATRYSSIHS LTRPGSLAVS DFDVSTNMDT VVKSQSNGYE EDSILKIIDN SDRPGDILRT 240
VHVPGTNVAH SVRFFNNHLF ASCSDDNILR FWDTRTADKP LWTLSEPKNG RLTSFDSSQV 300
TENLFVTGFS TGVIKLWDAR AVQLATTDLT HRQNGEEPIQ NEIAKLFHSG GDSVVDILFS 360
QTSATEFVTV GGTGNVYHWD MEYSFSRNDD DNEDEVRVAA PEELQGQCLK FFHTGGTRRS 420
SNQFGKRNTV ALHPVINDFV GTVDSDSLVT AYKPFLASDF IGRGYDD 468
Keyword

KW-0181--Complete proteome
KW-0469--Meiosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0034629--P:cellular protein complex localization
GO:0006974--P:cellular response to DNA damage stimulus
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0010674--P:negative regulation of transcription from RNA polymerase II promoter during meiosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated