dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016545
Uniprot Accession Q12205; MNL2_YEAST; D6VY59; Q7LGY1;
Genbank Protein ID NP_013158.1;
Genbank Nucleotide ID NM_001181944.1;
Protein Name Putative endoplasmic reticulum mannosidase MNL2
Protein Synonyms/Alias Mannosidase-like protein 2;
Gene Name MNL2
Gene Synonyms/Alias YLR057W;L2153;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD).
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
8MSIARLVYSLFRRVRcurated26040406
9SIARLVYSLFRRVRScurated26040406
497KSLIDSQTFLTNSIScurated22817900
500IDSQTFLTNSISNIFcurated22817900
673KAKRNVLSKDGITETPhosphoGRID 2.0;curated19823750; 19795423; 22817900
800LWQIKEFYENGEKVNcurated25315811
Sequence
(Fasta)
MSIARLVYSL FRRVRSVLLL FITISLLFYY TFQNEIDILN SYALNDSLPS INNYEHNTEG 60
SSKLDPPDLS STGSDRIATD KENGNVAVDL SDPATLREKN KYFPLLLKGS SHQIGSNLPI 120
SSLLTYKEKY PVLFEYSSPS LTSISQNDVH KIQPAMQLPP DVDMIKQIKD IFMKSWNQEQ 180
LLLKSNLRRE STWPIDLIDS LDTLYLCGET KLFQDSVNII EDFDFRVPPL AMEVIDIPDI 240
TTRVLEGLLS AYELSMDKRL LNKAKHVADF ILRSFDTPNR IPILKYFWKS DLRNRFPDRT 300
VPSGQLTTMA LAFIRLSQLT RLNKYFDAVE RVFTTIRQSY NEFDMEFMLP DVVDASGCQL 360
LTQEEIENGA HLKGSSIMKS INENFKFVHC QQLGKFLNPP IDDNSLQEQS QYQAYRINEK 420
TVPILENLFK INDLFQSSYD ILDGSSKNAN AATMDPSIGS EVEAVDEIIE KRNFKDGTKK 480
DSTKNTVGDK SLIDSQTFLT NSISNIFKFM TFRPMLPKQT ENKKFNFLNS ILTKSQFMPT 540
TNELDVTIRK SYDVSLYSCR LGGILGLSSR VPHRGGVNTK YILPSSLLEM SEIITESCFM 600
LMEEFDGLLP QKFELDPCTD ETNGNCEFNG ETKSRMIANG EYETFENDLD VGIKVSNYGK 660
GGNDQKAKRN VLSKDGITET QNIKGDTVGS SKSIAEIDGD EVTQIRRVFT LGKDIKPHIT 720
TDDTMGSQWK NHPDWPFWVN KVESRRLLDS NIIESIFYMY RISGEQKWRS MGKQSFGILM 780
QELMELNSGA KGLWQIKEFY ENGEKVNNDL PSYWFSRTLK YYLLLFSDGD KVSLDKHILT 840
QGGHIIKKK
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0472--Membrane
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001382--Glyco_hydro_47

PROSITE
Pfam

PF01532--Glyco_hydro_47

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005509--F:calcium ion binding
GO:0004571--F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0006491--P:N-glycan processing