dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016543
Uniprot Accession Q12200; NPC1_YEAST; D6W406;
Genbank Protein ID NP_015319.1;
Genbank Nucleotide ID NM_001183820.1;
Protein Name Niemann-Pick type C-related protein 1
Protein Synonyms/Alias
Gene Name NCR1
Gene Synonyms/Alias YPL006W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
794VDYFKDVYSFLNVGPcurated26040289
795DYFKDVYSFLNVGPPcurated26040289
804LNVGPPVYMVVKNLDcurated26040289
813VVKNLDLTKRQNQQKcurated26040289
882TDEVCPPSFPSRRCEcurated25704821
885VCPPSFPSRRCETCFcurated25704821
Sequence
(Fasta)		MNVLWIIALV GQLMRLVQGT ATCAMYGNCG KKSVFGNELP CPVPRSFEPP VLSDETSKLL 60
VEVCGEEWKE VRYACCTKDQ VVALRDNLQK AQPLISSCPA CLKNFNNLFC HFTCAADQGR 120
FVNITKVEKS KEDKDIVAEL DVFMNSSWAS EFYDSCKNIK FSATNGYAMD LIGGGAKNYS 180
QFLKFLGDAK PMLGGSPFQI NYKYDLANEE KEWQEFNDEV YACDDAQYKC ACSDCQESCP 240
HLKPLKDGVC KVGPLPCFSL SVLIFYTICA LFAFMWYYLC KRKKNGAMIV DDDIVPESGS 300
LDESETNVFE SFNNETNFFN GKLANLFTKV GQFSVENPYK ILITTVFSIF VFSFIIFQYA 360
TLETDPINLW VSKNSEKFKE KEYFDDNFGP FYRTEQIFVV NETGPVLSYE TLHWWFDVEN 420
FITEELQSSE NIGYQDLCFR PTEDSTCVIE SFTQYFQGAL PNKDSWKREL QECGKFPVNC 480
LPTFQQPLKT NLLFSDDDIL NAHAFVVTLL LTNHTQSANR WEERLEEYLL DLKVPEGLRI 540
SFNTEISLEK ELNNNNDIST VAISYLMMFL YATWALRRKD GKTRLLLGIS GLLIVLASIV 600
CAAGFLTLFG LKSTLIIAEV IPFLILAIGI DNIFLITHEY DRNCEQKPEY SIDQKIISAI 660
GRMSPSILMS LLCQTGCFLI AAFVTMPAVH NFAIYSTVSV IFNGVLQLTA YVSILSLYEK 720
RSNYKQITGN EETKESFLKT FYFKMLTQKR LIIIIFSAWF FTSLVFLPEI QFGLDQTLAV 780
PQDSYLVDYF KDVYSFLNVG PPVYMVVKNL DLTKRQNQQK ICGKFTTCER DSLANVLEQE 840
RHRSTITEPL ANWLDDYFMF LNPQNDQCCR LKKGTDEVCP PSFPSRRCET CFQQGSWNYN 900
MSGFPEGKDF MEYLSIWINA PSDPCPLGGR APYSTALVYN ETSVSASVFR TAHHPLRSQK 960
DFIQAYSDGV RISSSFPELD MFAYSPFYIF FVQYQTLGPL TLKLIGSAII LIFFISSVFL 1020
QNIRSSFLLA LVVTMIIVDI GALMALLGIS LNAVSLVNLI ICVGLGVEFC VHIVRSFTVV 1080
PSETKKDANS RVLYSLNTIG ESVIKGITLT KFIGVCVLAF AQSKIFDVFY FRMWFTLIIV 1140
AALHALLFLP ALLSLFGGES YRDDSIEAED 1171
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0443--Lipid metabolism
KW-0445--Lipid transport
KW-0472--Membrane
KW-1185--Reference proteome
KW-0732--Signal
KW-0746--Sphingolipid metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0926--Vacuole
Interpro

IPR032190--NPC1_N
IPR003392--Patched
IPR000731--SSD
PROSITE

PS50156--SSD
Pfam

PF16414--NPC1_N
PF02460--Patched
Gene Ontology

GO:0000329--C:fungal-type vacuole membrane
GO:0016021--C:integral component of membrane
GO:0008158--F:hedgehog receptor activity
GO:0046624--F:sphingolipid transporter activity
GO:0006665--P:sphingolipid metabolic process