dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016541
Uniprot Accession Q12196; RIO1_YEAST; D6W2H8; Q00602;
Genbank Protein ID NP_014762.3;
Genbank Nucleotide ID NM_001183538.3;
Protein Name Serine/threonine-protein kinase RIO1
Protein Synonyms/Alias Ribosomal RNA-processing protein 10;
Gene Name RIO1
Gene Synonyms/Alias RRP10;YOR119C;O3266;YOR3266C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
2------MSLEDKFDScurated24961812
38KIKTDELSFSRAKTScurated22817900; 19547744
354RSLHLVRSLGGLEERdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
402DNADHECSSGTEEFSdbPTM 3.0;PhosphoGRID 2.0-; 16381945; 23193290; 17725716
403NADHECSSGTEEFSDdbPTM 3.0;PhosphoGRID 2.017725716; 16381945; 23193290
409SSGTEEFSDDEEDGSdbPTM 3.0;PhosphoGRID 2.017725716; 16381945; 23193290
416SDDEEDGSSGSEEDDdbPTM 3.0;PhosphoGRID 2.017725716; 16381945; 23193290
417DDEEDGSSGSEEDDEdbPTM 3.0;PhosphoGRID 2.017725716; 16381945; 23193290
419EEDGSSGSEEDDEEEdbPTM 3.0;PhosphoGRID 2.017725716; 16381945; 23193290
Sequence
(Fasta)		MSLEDKFDSL SVSQGASDHI NNQLLEKYSH KIKTDELSFS RAKTSKDKAN RATVENVLDP 60
RTMRFLKSMV TRGVIADLNG CLSTGKEANV YHAFAGTGKA PVIDEETGQY EVLETDGSRA 120
EYAIKIYKTS ILVFKDRERY VDGEFRFRNS RSQHNPRKMI KIWAEKEFRN LKRIYQSGVI 180
PAPKPIEVKN NVLVMEFLSR GNGFASPKLK DYPYKNRDEI FHYYHTMVAY MRLLYQVCRL 240
VHADLSEYNT IVHDDKLYMI DVSQSVEPEH PMSLDFLRMD IKNVNLYFEK MGISIFPERV 300
IFQFVISETL EKFKGDYNNI SALVAYIASN LPIKSTEQDE AEDEIFRSLH LVRSLGGLEE 360
RDFDRYTDGK FDLLKSLIAH DNERNFAASE QFEFDNADHE CSSGTEEFSD DEEDGSSGSE 420
EDDEEEGEYY DDDEPKVLKG KKHEDKDLKK LRKQEAKDAK REKRKTKVKK HIKKKLVKKT 480
KSKK 485
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR000687--RIO_kinase
IPR018935--RIO_kinase_CS
IPR017407--Ser/Thr_kinase_Rio1
PROSITE

PS50011--PROTEIN_KINASE_DOM
PS01245--RIO1
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030874--C:nucleolar chromatin
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0007069--P:negative regulation of transcription from RNA polymerase I promoter during mitosis
GO:2000234--P:positive regulation of rRNA processing
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0007096--P:regulation of exit from mitosis