| Tag |
Content |
| dbPAF ID |
dbPAF-0016540 |
| Uniprot Accession |
Q12193; YB12B_YEAST; D6VQ13;
|
| Genbank Protein ID |
NP_009567.1;
|
| Genbank Nucleotide ID |
NM_001180056.2;
|
| Protein Name |
Transposon Ty1-BR Gag-Pol polyprotein |
| Protein Synonyms/Alias |
Gag-Pol-p199;TY1A-TY1B;Transposon Ty1 TYA-TYB polyprotein;p190; |
| Gene Name |
TY1B-BR |
| Gene Synonyms/Alias |
YBRWTy1-2 POL;YBR012W-B;YBR0207; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).Functional Description
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MESQQLSNYP HISHGSACAS VTSKEVHTNQ DPLDVSASKI QEYDKASTKA NSQQTTTPAS 60
SAVPENPHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG WSFYGHPSMI PYTPYQMSPM 120
YFPPGPQSQF PQYPSSVGTP LSTPSPESGN TFTDSSSADS DMTSTKKYVR PPPMLTSPND 180
FPNWVKTYIK FLQNSNLGGI IPTVNGKPVR PITDDELTFL YNAFQIFAPS QFLPTWVKDI 240
LSVDYTDIMK ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN 300
GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ QGSRNSKPNY 360
RRNPSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA HNVSTSNNSP STDNDSISKS 420
TTEPIQLNNK HDLHLGQKLT ESTVNHTNHS DDELPGHLLL DSGASRTLIR SAHHIHSASS 480
NPDINVVDAQ KRNIPINAIG DLQFHFQDNT KTSLKVLHTP NIAYDLLSLN ELAAVDITAC 540
FTKNVLERSD GTVLAPIVKY GDFYWVSKKY LLPSNISVPT INNVHTSEST RKYPYPFIHR 600
MLAHANAQTI RYSLKNNTIT YFNESDVDWS SAIDYQCPDC LIGKSTKHRH IKGSRLKYQN 660
SYEPFQYLHT DIFGPVHNLP KSAPSYFISF TDETTKFRWV YPLHDRREDS ILDVFTTILA 720
FIKNQFQASV LVIQMDRGSE YTNRTLHKFL EKNGITPCYT TTADSRAHGV AERLNRTLLD 780
DCRTQLQCSG LPNHLWFSAI EFSTIVRNSL ASPKSKKSAR QHAGLAGLDI STLLPFGQPV 840
IVNDHNPNSK IHPRGIPGYA LHPSRNSYGY IIYLPSLKKT VDTTNYVILQ GKDSRLDQFN 900
YDALTFDEDL NRLTASYQSF IASNEIQQSN DLNIESDHDF QSDIELYPEQ PRNVLSKAVS 960
PTDSTPPSTH TEDSKRVSKT NIRAPREVDP NISESNILPS KKRSSTPQIS DIESTDSGGM 1020
HRLDVPLLAP MSQSNTHESS YASKSKDFRH SDSYSDNETN HTNVPISSTG GTNNKTVPQT 1080
SEQETEKRII HRFTSDRILP SSESNSLHHV VPIKTSDTCF KENTEESIIA DLPLPDLPPE 1140
PPTELSDSFK ELPPINSRQT NSSLGGIGDS NAYTTINSKK RSLEDNETEI KVSRDTWNTK 1200
NMRSLEPPRS KKRIHLIAAV KAVKSIKPIR TTLRYDEAIT YNKDIKEKEK YIEAYHKEVN 1260
QLLKMKTWDT DKYYDRKEID PKRVINSMFI FNRKRDGTHK ARFVARGDIQ HPDTYDSGMQ 1320
SNTVHHYALM TSLSLALDNN YYITQLDISS AYLYADIKEE LYIRPPPHLG MNDKLIRLKK 1380
SLYGLKQSGA NWYETIKSYL IKQCGMEEVR GWSCVFKNSQ VTICLFVDDM ILFSKDLNSN 1440
KRIIAKLKMQ YDTKIINLGE SDDEIQHDIL GLEIKYQRGK YMKLGMENSL TEKIPKLNVP 1500
LNPNGRKLGA PGQPGLYINQ QELELEEDDY KMKVHEMQKL IGLASYVGYK FRFDLLYYIN 1560
TLAQHILFPS KQVLDMTYEL IQFIWNTRDK QLIWHKSKPV KPTNKLVVIS DASYGNQPYY 1620
KSQIGNIYLL NGKVIGGKST KASLTCTSTT EAEIHAISES VPLLNNLSYL IQELDKKPIT 1680
KGLLTDSKST ISIIISNNEE KFRNRFFGTK AMRLRDEVSG NHLHVCYIET KKNIADVMTK 1740
PLPIKTFKLL TNKWIH
1757Fasta Sequence
>Q12193|TY1B-BR|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNAFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSLKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKDSRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSNDLNIESDHDFQSDIELYPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTDSGGMHRLDVPLLAPMSQSNTHESSYASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRFTSDRILPSSESNSLHHVVPIKTSDTCFKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNSNKRIIAKLKMQYDTKIINLGESDDEIQHDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPNGRKLGAPGQPGLYINQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
|
| Keyword |
KW-0064--Aspartyl protease
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0229--DNA integration
KW-0233--DNA recombination
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0540--Nuclease
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0688--Ribosomal frameshifting
KW-0694--RNA-binding
KW-0695--RNA-directed DNA polymerase
KW-0808--Transferase
KW-0814--Transposable element
KW-0815--Transposition
KW-0917--Virion maturation
KW-1188--Virus exit from host cell
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR001969--Aspartic_peptidase_AS
IPR001584--Integrase_cat-core
IPR015820--Retrotransposon_Ty1A_N
IPR012337--RNaseH-like_dom
IPR013103--RVT_2
|
| PROSITE |
PS00141--ASP_PROTEASE
PS50994--INTEGRASE
|
| Pfam |
PF00665--rve
PF07727--RVT_2
PF01021--TYA
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000943--C:retrotransposon nucleocapsid
GO:0004190--F:aspartic-type endopeptidase activity
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0008233--F:peptidase activity
GO:0004540--F:ribonuclease activity
GO:0003723--F:RNA binding
GO:0003964--F:RNA-directed DNA polymerase activity
GO:0004523--F:RNA-DNA hybrid ribonuclease activity
GO:0071897--P:DNA biosynthetic process
GO:0015074--P:DNA integration
GO:0006310--P:DNA recombination
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0006278--P:RNA-dependent DNA replication
GO:0032197--P:transposition, RNA-mediated
GO:0019076--P:viral release from host cell
|
