dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016537
Uniprot Accession Q12188; REC8_YEAST; D6W418;
Genbank Protein ID NP_015332.1;
Genbank Nucleotide ID NM_001184104.1;
Protein Name Meiotic recombination protein REC8
Protein Synonyms/Alias Cohesin REC8;Sporulation protein 69;
Gene Name REC8
Gene Synonyms/Alias SPO69;YPR007C;LPZ7C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. Is protected from cleavage by SPO13.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
136NGLNSNNSIIGNKNNPhosphoGRID 2.020230747
172PALEFLNTTLQDNVSPhosphoGRID 2.020230747
173ALEFLNTTLQDNVSFPhosphoGRID 2.020230747
179TTLQDNVSFIEEAKSPhosphoGRID 2.020230747
197QDYINELSNSNRFELPhosphoGRID 2.020230747
209FELHGDMTNSDAQSNPhosphoGRID 2.020230747
211LHGDMTNSDAQSNLGPhosphoGRID 2.020230747
215MTNSDAQSNLGSNVRPhosphoGRID 2.020230747
219DAQSNLGSNVRNSFPPhosphoGRID 2.020230747
224LGSNVRNSFPLDEIPPhosphoGRID 2.020230747
245LDLDDIVSHQGTPLGPhosphoGRID 2.020230747
285ENDNENNSNGGEDTSPhosphoGRID 2.020230747
292SNGGEDTSVENEGPVPhosphoGRID 2.020230747
314LGLEAQASEEENDLQPhosphoGRID 2.020230747
386NFLTSNISSLVRSCGPhosphoGRID 2.020230747
387FLTSNISSLVRSCGEPhosphoGRID 2.020230747
425DLYPQGFSSVERGRKPhosphoGRID 2.020230747
426LYPQGFSSVERGRKRPhosphoGRID 2.020230747
436RGRKRAHSLVSTQSSPhosphoGRID 2.020230747
465NNKNDNYSSDMENDNPhosphoGRID 2.020230747
Sequence
(Fasta)		MAPLSLNFKD DKKYKGLTTV WLLSALGNSI VKESNNYYSN KSNSTGNISS STVKKKDIVN 60
ISIPKTCDEI QNFENDFSLR YISNLLYGVT ICYNKKTEYV LNDLNHLLVQ LQKNDVYAFK 120
AKNKSTRING LNSNNSIIGN KNNNYTWEEC VFFDDDPLYD ITKVPALEFL NTTLQDNVSF 180
IEEAKSIRRQ DYINELSNSN RFELHGDMTN SDAQSNLGSN VRNSFPLDEI PVDVDFNLDL 240
DDIVSHQGTP LGSHSSSQKD GNDFKFNYQG DELVLNFEND NENNSNGGED TSVENEGPVA 300
NLKDYELGLE AQASEEENDL QQKLNTRMQR GHRADVGGQF SKVQFDAKTS YPNEVLKFNH 360
GNYSHLMEKN RIRKLTGQNF LTSNISSLVR SCGEEEFFST NWLSIFNDFS NIKTSEWDLY 420
PQGFSSVERG RKRAHSLVST QSSSSTRSHE YGRKSFRNNK NDNYSSDMEN DNLLLNLEQI 480
NEDLEDGHYI EENSQGNILD FNLNLPPSSF GRSHTRNSTR SSGFNEDIVG ALRRRVGPSE 540
QNFAEEDDSS NSCFSDGSQQ NLQQDKTNFQ DVILDYQTKK FYDYIKERSI VVGRTTRSNP 600
PFKRKMLLVD IIPSRMGEAQ TGANFDDVER GVSRQIAASA FLSLLNLATK GMVKLNEYPV 660
ADAVTKDLKL RREDEIIVYA 681
Keyword

KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR023093--Rad21/Rec8_C
IPR006910--Rad21_Rec8_N
PROSITE
Pfam

PF04825--Rad21_Rec8_N
Gene Ontology

GO:0000794--C:condensed nuclear chromosome
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0051177--P:meiotic sister chromatid cohesion
GO:0071459--P:protein localization to chromosome, centromeric region
GO:0007131--P:reciprocal meiotic recombination
GO:0007130--P:synaptonemal complex assembly