| Tag |
Content |
| dbPAF ID |
dbPAF-0016533 |
| Uniprot Accession |
Q12181; NDOR1_YEAST; D6W456;
|
| Genbank Protein ID |
NP_015373.1;
|
| Genbank Nucleotide ID |
NM_001184145.1;
|
| Protein Name |
NADPH-dependent diflavin oxidoreductase 1 |
| Protein Synonyms/Alias |
NADPH-dependent FMN and FAD-containing oxidoreductase; |
| Gene Name |
TAH18 |
| Gene Synonyms/Alias |
YPR048W;YP9499.06; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe/S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe/S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of DRE2. Positively controls H(2)O(2)-induced cell death.Functional Description
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe/S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe/S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of DRE2. Positively controls H(2)O(2)-induced cell death. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 535 | KGKIALHSSFSRDEE | curated | 19823750 |
|
Sequence
(Fasta) | MSSSKKIVIL YGSETGNAHD FATILSHRLH RWHFSHTFCS IGDYDPQDIL KCRYLFIICS 60
TTGQGELPRN VNALKGERPV TFWSFLKRKN LPSNLLNHIQ TAMLGLGDSS YPKFNYGIRK 120
LHQRIVTQLG ANELFDRLEA DDQAMAGSNK GTGLGIESVY FEYEKKVLSF LLSKYPNRKV 180
NGQIIKREEL DPEVYLEPAS YLQLSDEHAN EKFTSTKVIF EGDESLKVGR VNINKRITSE 240
GHFQDVRQFK FSNVDKIQEN YEPGDTVTIY PCNTDEDVSR FLANQSHWLE IADKPLNFTS 300
GVPNDLKDGG LVRPMTLRNL LKYHCDFMSI PRTSFFLKIW TFATDVTKME RGQEQLNDQR 360
EKLRQFATDQ DMQDLYDYCN RPRRSILEVL EDFISVKLPW KYVLDYLPII KPRYYSISSG 420
PGDPNIELTV AIVKYKTILR KIRRGICTNY IARLQEGEQI RYKLQNNHII KKEFLNKPMI 480
LVGPGVGLAP LLSVVKAEIS KDIKLLFGCR YKDKDYIYKD MLEDWFRKGK IALHSSFSRD 540
EENSPGVKYV QDYLWRLGEE ITNLVVNKDA VFFLCGSSGK MPIQVRLTFI EMLKKWGNFS 600
DEETAKKYLK EMEKSDRYIQ ETW
624Fasta Sequence
>Q12181|TAH18|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFLNKPMILVGPGVGLAPLLSVVKAEISKDIKLLFGCRYKDKDYIYKDMLEDWFRKGKIALHSSFSRDEENSPGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0274--FAD
KW-0285--Flavoprotein
KW-0288--FMN
KW-0496--Mitochondrion
KW-0521--NADP
KW-0560--Oxidoreductase
KW-1185--Reference proteome
|
| Interpro |
IPR003097--FAD-binding_1
IPR017927--Fd_Rdtase_FAD-bd
IPR001094--Flavdoxin
IPR008254--Flavodoxin/NO_synth
IPR001709--Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039--Flavoprotein-like
IPR023173--NADPH_Cyt_P450_Rdtase_dom3
IPR028879--NDOR1
IPR001433--OxRdtase_FAD/NAD-bd
IPR017938--Riboflavin_synthase-like_b-brl
|
| PROSITE |
PS51384--FAD_FR
PS50902--FLAVODOXIN_LIKE
|
| Pfam |
PF00667--FAD_binding_1
PF00258--Flavodoxin_1
PF00175--NAD_binding_1
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0050660--F:flavin adenine dinucleotide binding
GO:0010181--F:FMN binding
GO:0005506--F:iron ion binding
GO:0050661--F:NADP binding
GO:0003958--F:NADPH-hemoprotein reductase activity
GO:0016651--F:oxidoreductase activity, acting on NAD(P)H
GO:0016709--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016226--P:iron-sulfur cluster assembly
GO:0006809--P:nitric oxide biosynthetic process
GO:0055114--P:oxidation-reduction process
|
