dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016529
Uniprot Accession Q12175; MSH5_YEAST; D6VRJ6;
Genbank Protein ID NP_010127.1;
Genbank Nucleotide ID NM_001180214.1;
Protein Name MutS protein homolog 5
Protein Synonyms/Alias
Gene Name MSH5
Gene Synonyms/Alias YDL154W;D1542;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
313KKRIETRYSIIRTLLcurated22817900
318TRYSIIRTLLDKQNAcurated22817900
735TDILDGPSLFGSIMLcurated22817900
739DGPSLFGSIMLNMSKcurated22817900
745GSIMLNMSKSEKCPRcurated22817900
Sequence
(Fasta)		MSHEWLISAS ETMRSIGNGE GLRDKGAVVA NNDGEFNEGD TNREEDSSTI FSFDFDEEIV 60
MCIDFSGGKL GCSILDYHTK TLKAFDQDYV VNKTTISSHD LIDDADMSSN DISLLLGLLI 120
MEANPTVCLV PARLEDWIFD YIKTKCDEIN CRLELQPIKR FKKWDLLQSL QLRGHDNQTI 180
LNDILSNSKF TTTVTLGTVG CILANHEQLG EYNDSTASSN MVTGRLVQNA FEDVIHGIRY 240
IDIRDRMVLD ENTISALHIF PTAHKLGHDK MMRNGFFSVF ELFNQVSSDY ARRILKSWLI 300
NPLTNKKRIE TRYSIIRTLL DKQNAIIFSD LSQSIKRCPD AFGFINQLRS GKSTLGTWSK 360
VASFLEKGIA IFQLVSSLKL GSDEANILHD IKNKVDISAL KECLRKVETV IDFDTSRDTK 420
TLTINTGVDN RLDECRNIYN HLEGILLDVA RETQIFLLNT MPQEDCKTTK SLEKLVNAVY 480
IPQLGYLVTI SVLMEPLLDG IPNLQWEEIF RSSENIYFKN GRVLELDETY GDIYGAISDF 540
EIEILFSLQE QILRRKTQLT AYNILLSELE ILLSFAQVSA ERNYAEPQLV EDECILEIIN 600
GRHALYETFL DNYIPNSTMI DGGLFSELSW CEQNKGRIIV VTGANASGKS VYLTQNGLIV 660
YLAQIGCFVP AERARIGIAD KILTRIRTQE TVYKTQSSFL LDSQQMAKSL SLATEKSLIL 720
IDEYGKGTDI LDGPSLFGSI MLNMSKSEKC PRIIACTHFH ELFNENVLTE NIKGIKHYCT 780
DILISQKYNL LETAHVGEDH ESEGITFLFK VKEGISKQSF GIYCAKVCGL SRDIVERAEE 840
LSRMINRGDD VVQQCGNLTE KEMREFQKNQ EIVKKFLSWD LDLETTTTSE NLRLKLKNFL 900
R 902
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
Interpro

IPR011184--DNA_mismatch_repair_MutS
IPR000432--DNA_mismatch_repair_MutS_C
IPR007696--DNA_mismatch_repair_MutS_core
IPR027417--P-loop_NTPase
PROSITE

PS00486--DNA_MISMATCH_REPAIR_2
Pfam

PF05192--MutS_III
PF00488--MutS_V
Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0000795--C:synaptonemal complex
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0030983--F:mismatched DNA binding
GO:0051026--P:chiasma assembly
GO:0045143--P:homologous chromosome segregation
GO:0006298--P:mismatch repair
GO:0007131--P:reciprocal meiotic recombination