dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016521
Uniprot Accession Q12158; SCC1_YEAST; D6VRY5; Q05325;
Genbank Protein ID NP_010281.1;
Genbank Nucleotide ID NM_001180062.1;
Protein Name Sister chromatid cohesion protein 1
Protein Synonyms/Alias
Gene Name MCD1
Gene Synonyms/Alias PDS3;RHC21;SCC1;YDL003W;YD8119.04;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
119STVNRLNTVTRVHQLPhosphoGRID 2.020190278
161GLMAQENSMERKVQGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
174QGAAPWDTSLEVGRRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 26040289
175GAAPWDTSLEVGRRFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 20702584; 19779198;
263NNDDDDNSVEQGRRLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 20489023; 20702584; 11371343;
307ITDAMTESQPKQTGTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20190278; 19366988; 25315811
349NTYKEERSNNLLTPQPhosphoGRID 2.020489023
354ERSNNLLTPQPTNFTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19060867; 19366988; 25315811
Sequence
(Fasta)		MVTENPQRLT VLRLATNKGP LAQIWLASNM SNIPRGSVIQ THIAESAKEI AKASGCDDES 60
GDNEYITLRT SGELLQGIVR VYSKQATFLL TDIKDTLTKI SMLFKTSQKM TSTVNRLNTV 120
TRVHQLMLED AVTEREVLVT PGLEFLDDTT IPVGLMAQEN SMERKVQGAA PWDTSLEVGR 180
RFSPDEDFEH NNLSSMNLDF DIEEGPITSK SWEEGTRQSS RNFDTHENYI QDDDFPLDDA 240
GTIGWDLGIT EKNDQNNDDD DNSVEQGRRL GESIMSEEPT DFGFDLDIEK EAPAGNIDTI 300
TDAMTESQPK QTGTRRNSKL LNTKSIQIDE ETENSESIAS SNTYKEERSN NLLTPQPTNF 360
TTKRLWSEIT ESMSYLPDPI LKNFLSYESL KKRKIHNGRE GSIEEPELNV SLNLTDDVIS 420
NAGTNDNSFN ELTDNMSDFV PIDAGLNEAP FPEENIIDAK TRNEQTTIQT EKVRPTPGEV 480
ASKAIVQMAK ILRKELSEEK EVIFTDVLKS QANTEPENIT KREASRGFFD ILSLATEGCI 540
GLSQTEAFGN IKIDAKPALF ERFINA 567
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR023093--Rad21/Rec8_C
IPR006909--Rad21/Rec8_C_eu
IPR006910--Rad21_Rec8_N
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF04824--Rad21_Rec8
PF04825--Rad21_Rec8_N
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0000794--C:condensed nuclear chromosome
GO:0005739--C:mitochondrion
GO:0034990--C:nuclear mitotic cohesin complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0006915--P:apoptotic process
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006268--P:DNA unwinding involved in DNA replication
GO:0006302--P:double-strand break repair
GO:0034087--P:establishment of mitotic sister chromatid cohesion
GO:0007076--P:mitotic chromosome condensation
GO:0006473--P:protein acetylation
GO:1990414--P:replication-born double-strand break repair via sister chromatid exchange