dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016516
Uniprot Accession Q12151; UPC2_YEAST; D6VSJ7;
Genbank Protein ID NP_010499.1;
Genbank Nucleotide ID NM_001180521.1;
Protein Name Sterol uptake control protein 2
Protein Synonyms/Alias Mannoprotein regulation by oxygen protein 4;
Gene Name UPC2
Gene Synonyms/Alias MOX4;YDR213W;YD8142.14;YD8142B.05;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
107KADGSVESDSSVDLPcurated20377248
109DGSVESDSSVDLPPTcurated20377248
110GSVESDSSVDLPPTIcurated20377248
122PTIKKEQTPFNDIQSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19060867; 19366988;
150SSASTTKSESEEKSScurated20377248
152ASTTKSESEEKSSAPcurated20377248
156KSESEEKSSAPIEDKcurated25315811
157SESEEKSSAPIEDKNcurated25315811
167IEDKNNMTPLSMGLQcurated25315811
170KNNMTPLSMGLQGTIcurated26040289
176LSMGLQGTINKKDMMcurated26040289
472KENDGQLSDTKSPAPcurated25521595; 25315811
516ERNMNRNSNISPSTPcurated22817900; 25315811
519MNRNSNISPSTPSAVdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 19779198; 19060867;
522NSNISPSTPSAVLNDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900
524NISPSTPSAVLNDRQPhosphoGRID 2.0;curated19779198; 22817900; 25315811
560PTISLQTSQTENEDDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
562ISLQTSQTENEDDAScurated25315811
584INNEADRSSVSAGTSdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 26040289;
585NNEADRSSVSAGTSNdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 26040406;
Sequence
(Fasta)		MSEVGIQNHK KAVTKPRRRE KVIELIEVDG KKVSTTSTGK RKFHNKSKNG CDNCKRRRVK 60
CDEGKPACRK CTNMKLECQY TPIHLRKGRG ATVVKYVTRK ADGSVESDSS VDLPPTIKKE 120
QTPFNDIQSA VKASGSSNDS FPSSASTTKS ESEEKSSAPI EDKNNMTPLS MGLQGTINKK 180
DMMNNFFSQN GTIGFGSPER LNSGIDGLLL PPLPSGNMGA FQLQQQQQVQ QQSQPQTQAQ 240
QASGTPNERY GSFDLAGSPA LQSTGMSLSN SLSGMLLCNR IPSGQNYTQQ QLQYQLHQQL 300
QLQQHQQVQL QQYQQLRQEQ HQQVQQQQQE QLQQYQQHFL QQQQQVLLQQ EQQPNDEEGG 360
VQEENSKKVK EGPLQSQTSE TTLNSDAATL QADALSQLSK MGLSLKSLST FPTAGIGGVS 420
YDFQELLGIK FPINNGNSRA TKASNAEEAL ANMQEHHERA AASVKENDGQ LSDTKSPAPS 480
NNAQGGSASI MEPQAADAVS TMAPISMIER NMNRNSNISP STPSAVLNDR QEMQDSISSL 540
GNLTKAALEN NEPTISLQTS QTENEDDASR QDMTSKINNE ADRSSVSAGT SNIAKLLDLS 600
TKGNLNLIDM KLFHHYCTKV WPTITAAKVS GPEIWRDYIP ELAFDYPFLM HALLAFSATH 660
LSRTETGLEQ YVSSHRLDAL RLLREAVLEI SENNTDALVA SALILIMDSL ANASGNGTVG 720
NQSLNSMSPS AWIFHVKGAA TILTAVWPLS ERSKFHNIIS VDLSDLGDVI NPDVGTITEL 780
VCFDESIADL YPVGLDSPYL ITLAYLDKLH REKNQGDFIL RVFTFPALLD KTFLALLMTG 840
DLGAMRIMRS YYKLLRGFAT EVKDKVWFLE GVTQVLPQDV DEYSGGGGMH MMLDFLGGGL 900
PSMTTTNFSD FSL 914
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR021858--DUF3468
IPR001138--Zn2-C6_fun-type_DNA-bd
PROSITE

PS00463--ZN2_CY6_FUNGAL_1
PS50048--ZN2_CY6_FUNGAL_2
Pfam

PF11951--Fungal_trans_2
PF00172--Zn_clus
Gene Ontology

GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0071456--P:cellular response to hypoxia
GO:0035961--P:positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:1900436--P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
GO:0035969--P:positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter