dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016506
Uniprot Accession Q12136; SAS10_YEAST; D6VRJ7; Q05842;
Genbank Protein ID NP_010128.1;
Genbank Nucleotide ID NM_001180213.1;
Protein Name Something about silencing protein 10
Protein Synonyms/Alias U three protein 3;U3 small nucleolar RNA-associated protein 3;U3 snoRNA-associated protein 11;
Gene Name SAS10
Gene Synonyms/Alias UTP3;YDL153C;D1545;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
12GSNRTKTSEVGDEINdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 19060867; 19366988;
46GQSTFGDSNKDDDHScurated25315811
53SNKDDDHSLLEDEDEcurated25704821; 25315811
72AMDEDDESIDEREDEcurated25704821; 25315811
300KEIWRQASELPSSFDPhosphoPep 2.019060867
314DVNEGDGSESEETANdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19684113; 19779198;
316NEGDGSESEETANIEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19684113; 19779198; 21081558;
319DGSESEETANIEAFNPhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;curated19823750; 19779198; 19795423; 21081558; 19060867; 22369663;
336KLNELQNSEDSDAEDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17563356; 18407956; 16381945; 23193290; 21177495;
339ELQNSEDSDAEDGGKdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17563356; 18407956; 16381945; 23193290; 21177495;
358IDEEERESDEEEEEEcurated24961812
475ADLDDKDYGSEDEAVPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19060867; 26040406; 22817900; 19823750; 25521595;
477LDDKDYGSEDEAVSRdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
483GSEDEAVSRSINTQGdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26447709
485EDEAVSRSINTQGENPhosphoGRID 2.0;curated19779198; 22817900; 19547744
488AVSRSINTQGENDYYcurated22817900; 19547744
494NTQGENDYYQQVQRGcurated19823750
533AELAENVSGDGKRAIPhosphoGRID 2.0;PhosphoPep 2.0;curated19823750; 19795423; 19060867; 26040289; 22817900; 24961812;
578KAQKKLKSVRAVYSGcurated24603354
583LKSVRAVYSGGQSGVcurated24603354
Sequence
(Fasta)		MVRKGSNRTK TSEVGDEINP YGLNEVDDFA SKREKVLLGQ STFGDSNKDD DHSLLEDEDE 60
EEVLAMDEDD ESIDEREDEE EEEEEELDGA AAYKKIFGRN LETDQLPEED EENGMLDNEN 120
AWGSTKGEYY GADDLDDDEA AKEIEKEALR QQKKHLEELN MNDYLDEEEE EEWVKSAKEF 180
DMGEFKNSTK QADTKTSITD ILNMDDEARD NYLRTMFPEF APLSKEFTEL APKFDELKKS 240
EENEFNKLKL IALGSYLGTI SCYYSILLHE LHNNEDFTSM KGHPVMEKIL TTKEIWRQAS 300
ELPSSFDVNE GDGSESEETA NIEAFNEKKL NELQNSEDSD AEDGGKQKQE IDEEERESDE 360
EEEEEDVDID DFEEYVAQSR LHSKPKTSSM PEADDFIESE IADVDAQDKK ARRRTLRFYT 420
SKIDQQENKK TDRFKGDDDI PYKERLFERQ QRLLDEARKR GMHDNNGADL DDKDYGSEDE 480
AVSRSINTQG ENDYYQQVQR GKQDKKISRK EAHKNAVIAA REGKLAELAE NVSGDGKRAI 540
NYQILKNKGL TPKRNKDNRN SRVKKRKKYQ KAQKKLKSVR AVYSGGQSGV YEGEKTGIKK 600
GLTRSVKFKN 611
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
Interpro

IPR007146--Sas10/Utp3/C1D
IPR018972--Sas10_C_dom
PROSITE
Pfam

PF09368--Sas10
PF04000--Sas10_Utp3
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0032040--C:small-subunit processome
GO:0007049--P:cell cycle
GO:0000480--P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000447--P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5
8S rRNA an-- LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000472--P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)