| Tag |
Content |
| dbPAF ID |
dbPAF-0016501 |
| Uniprot Accession |
Q12126; CRK1_SCHPO;
|
| Genbank Protein ID |
NP_596349.1;
|
| Genbank Nucleotide ID |
NM_001022269.2;
|
| Protein Name |
Serine/threonine-protein kinase crk1 |
| Protein Synonyms/Alias |
Mitotic catastrophe suppressor 6; |
| Gene Name |
crk1 |
| Gene Synonyms/Alias |
mcs6;mop1;SPBC19F8.07; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II.Functional Description
Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MDIEKSDKWT YVKERKVGEG TYAVVFLGRQ KETNRRVAIK KIKVGQFKDG IDISALREIK 60
FLRESRHDNV IELVDVFSTK SNLNIILEFL DSDLEMLIKD KFIVFQPAHI KSWMVMLLRG 120
LHHIHSRFIL HRDLKPNNLL ISSDGVLKLA DFGLSRDFGT PSHMSHQVIT RWYRPPELFM 180
GCRSYGTGVD MWSVGCIFAE LMLRTPYLPG ESDLDQLNVI FRALGTPEPE VIKSMQQLPN 240
YVEMKHIPPP NGGMEALFSA AGHEEIDLLK MMLDYNPYRR PTAQQALEHH YFSALPKPTH 300
PSLLPRKGGE EGIKHVSSDL QRQNNFPMRA NIKFV
336Fasta Sequence
>Q12126|crk1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MDIEKSDKWTYVKERKVGEGTYAVVFLGRQKETNRRVAIKKIKVGQFKDGIDISALREIKFLRESRHDNVIELVDVFSTKSNLNIILEFLDSDLEMLIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSDGVLKLADFGLSRDFGTPSHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRALGTPEPEVIKSMQQLPNYVEMKHIPPPNGGMEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSALPKPTHPSLLPRKGGEEGIKHVSSDLQRQNNFPMRANIKFV
|
| Keyword |
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005675--C:holo TFIIH complex
GO:0005634--C:nucleus
GO:0070985--C:TFIIK complex
GO:0005524--F:ATP binding
GO:0019912--F:cyclin-dependent protein kinase activating kinase activity
GO:0097472--F:cyclin-dependent protein kinase activity
GO:0004693--F:cyclin-dependent protein serine/threonine kinase activity
GO:0008353--F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0070817--P:P-TEFb-cap methyltransferase complex localization
GO:1903655--P:phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
GO:1903654--P:phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
GO:1904031--P:positive regulation of cyclin-dependent protein kinase activity
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0006351--P:transcription, DNA-templated
|
