dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016498
Uniprot Accession Q12123; DCS2_YEAST; D6W2M9;
Genbank Protein ID NP_014816.2;
Genbank Nucleotide ID NM_001183592.1;
Protein Name Inactive diphosphatase DCS2
Protein Synonyms/Alias Histidine triad protein;Protein Dcs2p;
Gene Name DCS2
Gene Synonyms/Alias YOR173W;O3625;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Plays a role in the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Stress-induced regulatory protein that modulates the m7GpppX diphosphatase activity of DCS1.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
3-----MGSQDLASLIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
8MGSQDLASLIGRFKYcurated22369663
58DETVRRPSQSGRSTPPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19779198; 19060867; 26040406; 22369663; 22817900;
60TVRRPSQSGRSTPIFPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19060867; 26040406; 22817900
63RPSQSGRSTPIFFHRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 19779198; 20702584;
64PSQSGRSTPIFFHREdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 21177495; 19779198;
166KWVNNILYEGAEDDRcurated22817900
340LKHDGIATSPEKGSGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20702584; 19823750;
341KHDGIATSPEKGSGFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21177495; 19060867;
Sequence
(Fasta)		MGSQDLASLI GRFKYVRVLD SNPHTKVISL LGSIDGKDAV LTAEKTHFIF DETVRRPSQS 60
GRSTPIFFHR EIDEYSFLNG ITDLKELTSN DIYYWGLSVL KQHILHNPTA KVNLIWPASQ 120
FHIKGYDQQD LHVVRETPDM YRNIVVPFIQ EMCTSERMKW VNNILYEGAE DDRVVYKEYS 180
SRNKEDGFVI LPDMKWDGIN IDSLYLVAIV YRDDIKSLRD LNPNHRDWLI RLNKKIKTII 240
PQHYDYNVNP DELRVFIHYQ PSYYHFHVHI VNIRHPGVGE ERGSGMTILL EDVIEALGFL 300
GPEGYMKKTL TYVIGENHDL WKKGFKEEVE KQLKHDGIAT SPEKGSGFNT NLG 354
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0866--Nonsense-mediated mRNA decay
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR008594--DcpS/DCS2
IPR019808--Histidine_triad_CS
IPR011146--HIT-like
IPR011145--Scavenger_mRNA_decap_enz_N
PROSITE

PS00892--HIT_1
Pfam

PF05652--DcpS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000932--C:cytoplasmic mRNA processing body
GO:0048471--C:perinuclear region of cytoplasm
GO:0004857--F:enzyme inhibitor activity
GO:0016787--F:hydrolase activity
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0031670--P:cellular response to nutrient
GO:0000290--P:deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0043086--P:negative regulation of catalytic activity
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0090342--P:regulation of cell aging
GO:0009408--P:response to heat
GO:0007584--P:response to nutrient
GO:0006970--P:response to osmotic stress
GO:0006979--P:response to oxidative stress